Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 39491..40151 Replicon chromosome
Accession NZ_CP016337
Organism Kosakonia sacchari strain BO-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BBB57_RS00200 Protein ID WP_065368121.1
Coordinates 39491..39844 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BBB57_RS00205 Protein ID WP_065368122.1
Coordinates 39849..40151 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBB57_RS00180 34757..35497 + 741 WP_065368119.1 adenosylcobinamide-GDP ribazoletransferase -
BBB57_RS00185 35525..36583 + 1059 WP_065368120.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -
BBB57_RS00190 36621..36932 - 312 WP_017458424.1 helix-turn-helix domain-containing protein -
BBB57_RS00195 37170..39272 + 2103 WP_020454243.1 elongation factor G -
BBB57_RS00200 39491..39844 + 354 WP_065368121.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBB57_RS00205 39849..40151 + 303 WP_065368122.1 helix-turn-helix transcriptional regulator Antitoxin
BBB57_RS00210 40234..41184 + 951 WP_065368123.1 L,D-transpeptidase -
BBB57_RS00215 41328..42353 + 1026 WP_065368124.1 LLM class flavin-dependent oxidoreductase -
BBB57_RS00220 42540..43016 + 477 WP_065368125.1 cold shock domain-containing protein -
BBB57_RS00225 43257..43796 + 540 WP_065368126.1 DUF2058 domain-containing protein -
BBB57_RS00230 43834..44079 + 246 WP_017458416.1 YmjA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 44144..45304 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13630.87 Da        Isoelectric Point: 10.0009

>T64449 WP_065368121.1 NZ_CP016337:39491-39844 [Kosakonia sacchari]
VWQIIMTQTFEKWFDALGDNDRASVLAALMVLRVKGPQLPRPYADTVKGSRYNNMKELRIQSRGEPFRVFYAFDPQRVGI
LLCAGNKASHEKRFYDVMIQIADLELTHHLHKIKIKE

Download         Length: 354 bp

>T64449 NZ_CP016337:39491-39844 [Kosakonia sacchari]
GTGTGGCAGATAATAATGACGCAGACGTTTGAAAAGTGGTTTGATGCACTGGGTGACAACGATCGCGCCAGTGTGCTGGC
GGCGCTGATGGTGCTCCGGGTTAAAGGTCCACAGCTACCAAGACCTTACGCGGATACAGTAAAAGGCTCGCGTTATAACA
ATATGAAAGAGTTGCGCATACAAAGCCGGGGCGAACCGTTTCGGGTTTTCTATGCCTTCGATCCGCAGCGCGTGGGAATA
TTGCTTTGCGCTGGCAACAAGGCGAGCCATGAAAAACGTTTTTACGATGTGATGATCCAGATTGCAGATCTGGAGCTAAC
GCACCATCTGCACAAGATTAAAATCAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11235.04 Da        Isoelectric Point: 7.2032

>AT64449 WP_065368122.1 NZ_CP016337:39849-40151 [Kosakonia sacchari]
MSKTLEQLIAEQKTNVVTAAQSLAQEMLLNIHLAELRERVQKTQIEMAQELGLKQPTVAVMEKQGRDIKLSTLKRYVEAT
GSKLRIDIELPDGSHYGFAL

Download         Length: 303 bp

>AT64449 NZ_CP016337:39849-40151 [Kosakonia sacchari]
ATGAGCAAAACGCTGGAACAGCTAATTGCCGAACAAAAGACCAATGTTGTCACCGCTGCGCAGTCACTTGCGCAAGAGAT
GCTGCTCAACATCCACCTGGCCGAGCTGCGTGAGCGGGTACAAAAAACGCAGATCGAAATGGCGCAGGAGTTGGGGCTGA
AACAACCGACGGTAGCGGTGATGGAAAAGCAGGGGCGGGACATTAAACTTTCCACGCTGAAGCGCTACGTGGAAGCGACA
GGCAGCAAGCTACGCATTGATATTGAGCTGCCGGATGGCTCACACTATGGCTTTGCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References