Detailed information of TA system TA064388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1733526..1734244
• Replicon: chromosome
• Accession: NZ_CP016303
• Organism: Candidatus Hamiltonella defensa (Bemisia tabaci) strain MEAM1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A249E1R2
• Locus tag: BA171_RS08320
• Protein ID: WP_016858021.1
• Coordinates: 1733526..1733837 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BA171_RS08325
• Protein ID: WP_016858020.1
• Coordinates: 1733834..1734244 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BA171_RS08595	1728590..1728766	-	177	WP_016858198.1	hypothetical protein	-
BA171_RS08280	1728831..1729252	+	422	Protein_1600	recombinase family protein	-
BA171_RS08285	1729438..1729695	+	258	WP_016858121.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
BA171_RS08290	1729692..1730111	+	420	WP_102135345.1	type II toxin-antitoxin system VapC family toxin	-
BA171_RS08300	1730685..1731320	+	636	WP_046493697.1	ParA family protein	-
BA171_RS08305	1731313..1731612	+	300	WP_046493696.1	hypothetical protein	-
BA171_RS08315	1732023..1732766	-	744	WP_157727316.1	hypothetical protein	-
BA171_RS08600	1733074..1733223	+	150	WP_157872093.1	hypothetical protein	-
BA171_RS08320	1733526..1733837	+	312	WP_016858021.1	type II toxin-antitoxin system HigB family toxin	Toxin
BA171_RS08325	1733834..1734244	+	411	WP_016858020.1	helix-turn-helix domain-containing protein	Antitoxin
BA171_RS08330	1734268..1734516	+	249	Protein_1609	ATP-binding protein	-
BA171_RS08335	1734514..1734675	-	162	Protein_1610	ParA family protein	-
BA171_RS08715	1734732..1734887	+	156	Protein_1611	transcriptional regulator	-
BA171_RS08345	1734937..1735132	-	196	Protein_1612	helix-turn-helix domain-containing protein	-
BA171_RS08350	1735734..1736009	-	276	WP_016858265.1	hypothetical protein	-
BA171_RS08355	1736388..1738379	-	1992	WP_095591403.1	cytochrome o ubiquinol oxidase subunit I	-
BA171_RS08605	1738383..1738559	-	177	WP_157727320.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1734937..1735068	131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Antitoxin HigA (2-136)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12729.59 Da
• Isoelectric Point: 9.8597

>T64388 WP_016858021.1 NZ_CP016303:1733526-1733837 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
MHVISKEPFEVAYRKYGRDSYAIVSTYRSLKENNFKNPDELKNLFPSLDKFKYREKWWVIDIGENNLRLIVYINFINKRI
YVKHIVTHSEYEKLNKYYRENKE

Nucleotide

• Length: 312 bp

>T64388 NZ_CP016303:1733526-1733837 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
ATGCACGTAATATCAAAAGAACCCTTTGAGGTAGCCTATAGAAAGTATGGGAGAGACTCTTATGCAATAGTCTCAACGTA
TCGATCTCTGAAAGAAAATAATTTTAAAAATCCGGATGAGCTAAAAAATCTTTTTCCCAGTTTAGATAAATTTAAGTATA
GAGAAAAATGGTGGGTCATTGATATTGGTGAAAATAATTTAAGGCTTATTGTTTATATTAATTTTATAAATAAACGAATT
TACGTCAAACATATCGTGACACATTCGGAGTACGAAAAATTAAACAAATATTATAGGGAGAATAAAGAATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15274.62 Da
• Isoelectric Point: 5.6250

>AT64388 WP_016858020.1 NZ_CP016303:1733834-1734244 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
MITEAIHATKELVKAVPLLGGSHSQSDYKAALELVNYLIDKDDENPLIDILSIKISEYEENSEQFCEFNKALEAMPTGVA
VLRVLMDQYHLKQTDLKNEIGSKSLVSQILNGKRSLTIAHIRALSARFNVRCELFI

Nucleotide

• Length: 411 bp

>AT64388 NZ_CP016303:1733834-1734244 [Candidatus Hamiltonella defensa (Bemisia tabaci)]
ATGATCACAGAAGCTATCCATGCAACAAAAGAACTGGTAAAAGCCGTTCCACTACTGGGTGGAAGTCATTCTCAGTCAGA
TTATAAAGCGGCTCTTGAGTTGGTCAATTATCTGATTGATAAAGATGATGAGAATCCTTTAATTGATATTTTGTCTATCA
AAATTTCGGAATATGAAGAAAATAGCGAACAGTTTTGTGAATTTAATAAAGCGCTTGAAGCTATGCCAACTGGAGTGGCT
GTTCTACGTGTATTAATGGATCAATATCATTTAAAACAAACTGATTTGAAGAATGAAATAGGTTCCAAGTCGTTAGTTAG
CCAAATATTAAATGGAAAACGCTCATTAACTATTGCTCATATTAGAGCTTTATCAGCACGTTTTAACGTGCGCTGTGAAT
TATTTATTTAA

Structures

Toxin

• AlphaFold DB: A0A249E1R2