Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 66044..66702 Replicon plasmid pCMCVTAb2-Ab66
Accession NZ_CP016302
Organism Acinetobacter baumannii strain CMC-CR-MDR-Ab66

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AOT18_RS20390 Protein ID WP_000312250.1
Coordinates 66343..66702 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AOT18_RS20385 Protein ID WP_001096429.1
Coordinates 66044..66343 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT18_RS20345 61902..62354 + 453 Protein_74 hypothetical protein -
AOT18_RS20350 62459..62716 + 258 WP_000834290.1 hypothetical protein -
AOT18_RS20355 62721..63293 + 573 WP_000443897.1 hypothetical protein -
AOT18_RS20360 63463..64092 + 630 WP_000701004.1 hypothetical protein -
AOT18_RS20365 64132..64350 + 219 WP_001043201.1 hypothetical protein -
AOT18_RS20370 64370..64925 + 556 Protein_79 hypothetical protein -
AOT18_RS20375 64975..65508 + 534 Protein_80 hypothetical protein -
AOT18_RS20385 66044..66343 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
AOT18_RS20390 66343..66702 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOT18_RS20395 66902..67468 + 567 WP_000710385.1 hypothetical protein -
AOT18_RS20400 67517..67699 + 183 WP_000373385.1 hypothetical protein -
AOT18_RS20405 67766..68464 + 699 WP_000873188.1 hypothetical protein -
AOT18_RS20410 68603..68986 + 384 WP_000654348.1 hypothetical protein -
AOT18_RS20415 69053..69811 + 759 WP_001053127.1 hypothetical protein -
AOT18_RS20425 70866..71180 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..73188 73188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T64385 WP_000312250.1 NZ_CP016302:c66702-66343 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T64385 NZ_CP016302:c66702-66343 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT64385 WP_001096429.1 NZ_CP016302:c66343-66044 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT64385 NZ_CP016302:c66343-66044 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References