Detailed information of TA system TA064376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 916925..917520
• Replicon: chromosome
• Accession: NZ_CP016294
• Organism: Stenotrophomonas rhizophila strain QL-P4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1B2N0W5
• Locus tag: BAY15_RS03980
• Protein ID: WP_068849197.1
• Coordinates: 917254..917520 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BAY15_RS03975
• Protein ID: WP_068849195.1
• Coordinates: 916925..917254 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAY15_RS03950	912748..913212	+	465	WP_068849185.1	RcnB family protein	-
BAY15_RS03955	913332..914585	+	1254	WP_068849187.1	serine hydroxymethyltransferase	-
BAY15_RS03960	914585..915028	+	444	WP_068849189.1	hypothetical protein	-
BAY15_RS03965	915122..915643	+	522	WP_068849191.1	transcriptional regulator NrdR	-
BAY15_RS03970	915751..916833	+	1083	WP_083214064.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
BAY15_RS03975	916925..917254	-	330	WP_068849195.1	transcriptional regulator	Antitoxin
BAY15_RS03980	917254..917520	-	267	WP_068849197.1	hypothetical protein	Toxin
BAY15_RS03985	917730..918362	-	633	WP_068849199.1	hypothetical protein	-
BAY15_RS03990	918738..919349	+	612	WP_068849201.1	riboflavin synthase	-
BAY15_RS03995	919346..920461	+	1116	WP_068849203.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
BAY15_RS04000	920645..921112	+	468	WP_068854542.1	6,7-dimethyl-8-ribityllumazine synthase	-
BAY15_RS04005	921109..921588	+	480	WP_068849204.1	transcription antitermination factor NusB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-93)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9956.53 Da
• Isoelectric Point: 10.0053

>T64376 WP_068849197.1 NZ_CP016294:c917520-917254 [Stenotrophomonas rhizophila]
MHAVFVEMPAFSRHRAAYLDNDGLCALQQFLLRAPEAGDVIVGTGGLRKLRFSDDRRQRGKGVQDDLDAMQKRLLKRMLE
AELLARTT

Nucleotide

• Length: 267 bp

>T64376 NZ_CP016294:c917520-917254 [Stenotrophomonas rhizophila]
ATGCACGCCGTGTTCGTGGAGATGCCGGCGTTCTCGCGCCACCGTGCCGCCTACCTCGACAACGATGGGCTCTGCGCGCT
TCAGCAGTTCCTGCTGCGGGCGCCGGAGGCTGGAGACGTGATCGTAGGCACTGGCGGTCTCCGCAAGCTGCGCTTTTCCG
ACGACCGCAGGCAGCGTGGCAAGGGCGTCCAGGACGACCTGGACGCGATGCAGAAAAGACTGCTGAAAAGAATGCTTGAG
GCCGAACTTCTGGCGAGGACCACATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12447.30 Da
• Isoelectric Point: 10.5713

>AT64376 WP_068849195.1 NZ_CP016294:c917254-916925 [Stenotrophomonas rhizophila]
MKRDVFAELVEGLHALEDERSGKSTLRTHKVRLQPLPPLHAGELVAIREQLNMSRPVFAMYLRTNARTLENWEQGRARPN
AQASTLIRLVQQFPQTVRHLEALQPDVAS

Nucleotide

• Length: 330 bp

>AT64376 NZ_CP016294:c917254-916925 [Stenotrophomonas rhizophila]
ATGAAACGCGACGTATTTGCCGAGCTTGTCGAAGGGCTGCACGCGCTGGAGGACGAGCGCTCGGGGAAGAGCACGCTGCG
CACGCACAAGGTTCGACTGCAGCCGTTGCCCCCGCTGCATGCGGGAGAGCTGGTCGCGATCCGTGAACAGCTGAACATGT
CACGGCCGGTGTTTGCCATGTACCTGCGTACCAATGCTCGCACGCTGGAGAACTGGGAGCAGGGCCGCGCGCGTCCCAAC
GCGCAGGCATCGACCCTCATTCGACTGGTGCAACAGTTTCCACAGACCGTTCGCCACCTGGAGGCGCTGCAGCCGGACGT
CGCCTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1B2N0W5