Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1292847..1293379 Replicon chromosome
Accession NZ_CP016279
Organism Streptomyces griseochromogenes strain ATCC 14511

Toxin (Protein)


Gene name yoeB Uniprot ID L1KUL2
Locus tag AVL59_RS06130 Protein ID WP_009321768.1
Coordinates 1293125..1293379 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B1ARN2
Locus tag AVL59_RS06125 Protein ID WP_067300168.1
Coordinates 1292847..1293128 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVL59_RS06105 1289032..1290048 + 1017 WP_099053008.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
AVL59_RS06110 1290101..1290850 + 750 WP_067300166.1 ROK family protein -
AVL59_RS06115 1290874..1291422 - 549 WP_208870317.1 hypothetical protein -
AVL59_RS06120 1291607..1292695 + 1089 WP_067300167.1 redox-regulated ATPase YchF -
AVL59_RS06125 1292847..1293128 + 282 WP_067300168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AVL59_RS06130 1293125..1293379 + 255 WP_009321768.1 Txe/YoeB family addiction module toxin Toxin
AVL59_RS06135 1293497..1295377 - 1881 WP_067300169.1 DUF2075 domain-containing protein -
AVL59_RS06140 1295488..1297545 - 2058 WP_067300170.1 DUF2075 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(2-64)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.61 Da        Isoelectric Point: 8.4390

>T64363 WP_009321768.1 NZ_CP016279:1293125-1293379 [Streptomyces griseochromogenes]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T64363 NZ_CP016279:1293125-1293379 [Streptomyces griseochromogenes]
GTGAGGCTTGTCTTCGAGGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTCGCTCGGAT
CAACAAACTCATCGAGGACGTCAAGCGTGACCCCTTCACGGGGATCGGCAAGCCCGAGCCGTTGAAGTACCACTTGCCCG
GGGCGTGGTCGAGACGGATCGACGATGAGCACCGCCTTGTGTACCTGGTCACGGACAAGGAGATCGTGATCCTCGCGGCT
CGCTATCACTACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10047.29 Da        Isoelectric Point: 4.8307

>AT64363 WP_067300168.1 NZ_CP016279:1292847-1293128 [Streptomyces griseochromogenes]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPVNARRLLKAYENALSNVNVSEREL
IDPDAADPAAGDA

Download         Length: 282 bp

>AT64363 NZ_CP016279:1292847-1293128 [Streptomyces griseochromogenes]
ATGTCGATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACGACCACGAGGCCATCGA
GATCGTCTCCAAGCATGGCAACGCCGTGCTTGTCTCGGCCGAGGACTACGCGGCGCTGCGCGAGGGCTCGTACCTGCTGC
GCTCGCCTGTGAACGCACGGCGACTGCTCAAGGCGTACGAGAATGCCCTGAGCAACGTCAACGTGTCGGAGCGCGAGCTG
ATCGATCCAGATGCGGCGGATCCTGCTGCGGGTGACGCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A540PPG9


Antitoxin

Source ID Structure
AlphaFold DB A0A1B1ARN2

References