Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 701442..702136 Replicon chromosome
Accession NZ_CP016273
Organism Yersinia pestis strain Cadman

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag BAY22_RS03105 Protein ID WP_002214787.1
Coordinates 701840..702136 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag BAY22_RS03100 Protein ID WP_002209924.1
Coordinates 701442..701840 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAY22_RS03065 696634..696999 + 366 WP_002209919.1 hypothetical protein -
BAY22_RS03070 697012..697248 + 237 WP_002214792.1 hypothetical protein -
BAY22_RS03075 697254..697586 + 333 WP_002214791.1 hypothetical protein -
BAY22_RS03080 697768..697967 + 200 Protein_584 AlpA family transcriptional regulator -
BAY22_RS24955 697981..698133 - 153 WP_002209921.1 hypothetical protein -
BAY22_RS03090 698126..698452 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
BAY22_RS03095 698752..701043 + 2292 WP_002209923.1 toprim domain-containing protein -
BAY22_RS03100 701442..701840 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BAY22_RS03105 701840..702136 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
BAY22_RS03110 702300..702662 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
BAY22_RS03115 702725..702985 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
BAY22_RS03125 703583..703768 + 186 WP_002209928.1 hypothetical protein -
BAY22_RS03130 703850..705064 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
BAY22_RS03140 705497..707014 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T64347 WP_002214787.1 NZ_CP016273:c702136-701840 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T64347 NZ_CP016273:c702136-701840 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT64347 WP_002209924.1 NZ_CP016273:c701840-701442 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT64347 NZ_CP016273:c701840-701442 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References