Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 568610..569214 Replicon chromosome
Accession NZ_CP016176
Organism Xenorhabdus hominickii strain ANU1

Toxin (Protein)


Gene name higB Uniprot ID A0A2G0Q5Z0
Locus tag A9255_RS02715 Protein ID WP_069315354.1
Coordinates 568610..568921 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A077PII1
Locus tag A9255_RS02720 Protein ID WP_038243532.1
Coordinates 568924..569214 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9255_RS02675 564002..565018 - 1017 WP_069315348.1 tyrosine-type recombinase/integrase -
A9255_RS02680 565021..565242 - 222 WP_069315349.1 DUF4224 domain-containing protein -
A9255_RS02685 565424..565633 - 210 WP_069315350.1 hypothetical protein -
A9255_RS02690 565630..566166 - 537 WP_069315351.1 phage N-6-adenine-methyltransferase -
A9255_RS20840 566144..566329 - 186 WP_071933827.1 hypothetical protein -
A9255_RS02695 566341..566736 - 396 WP_145957451.1 hypothetical protein -
A9255_RS02710 567653..568483 + 831 WP_069315353.1 restriction endonuclease -
A9255_RS02715 568610..568921 + 312 WP_069315354.1 toxin HigB-2 Toxin
A9255_RS02720 568924..569214 + 291 WP_038243532.1 helix-turn-helix domain-containing protein Antitoxin
A9255_RS02725 569229..569576 - 348 WP_069315355.1 Arc family DNA-binding protein -
A9255_RS22865 569709..569882 + 174 WP_169928429.1 hypothetical protein -
A9255_RS02730 569985..570593 + 609 WP_069315356.1 KilA-N domain-containing protein -
A9255_RS02735 570544..571641 - 1098 Protein_532 type VI secretion system tip protein VgrG -
A9255_RS02740 571678..573416 - 1739 Protein_533 type VI secretion system baseplate subunit TssF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 566850..567203 353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11929.64 Da        Isoelectric Point: 8.8403

>T64295 WP_069315354.1 NZ_CP016176:568610-568921 [Xenorhabdus hominickii]
MIFIETSIFTEDCKELLSDDEYREFQQYLADNPASGDVIQHTGGLRKVRWASRGKGKRGGVRVIYYHKVDVSHIRLLLIY
KKGIKDDLSESEKKVLRALNEGW

Download         Length: 312 bp

>T64295 NZ_CP016176:568610-568921 [Xenorhabdus hominickii]
ATGATATTCATTGAGACCTCTATATTCACCGAAGACTGTAAAGAGCTGTTAAGTGATGATGAGTATCGCGAGTTTCAGCA
ATATCTTGCAGACAATCCCGCTTCGGGTGATGTTATCCAGCACACTGGGGGCTTACGTAAAGTCAGATGGGCATCCAGAG
GTAAAGGTAAACGTGGCGGTGTACGCGTCATTTATTATCACAAGGTCGATGTCTCACATATAAGACTGCTGCTGATTTAT
AAAAAAGGCATTAAAGATGACCTTAGCGAGTCAGAAAAGAAAGTCTTGAGAGCATTAAATGAGGGATGGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10641.35 Da        Isoelectric Point: 10.7721

>AT64295 WP_038243532.1 NZ_CP016176:568924-569214 [Xenorhabdus hominickii]
MDSKLFSRLTESMTQMNEIMNGERAASRETTIEAVKVKNIRQTTGLSQAGFAKLISVNVGTLRNWEQGRREPTGPAKALL
KAIEKDPLHVLKALSM

Download         Length: 291 bp

>AT64295 NZ_CP016176:568924-569214 [Xenorhabdus hominickii]
ATGGATAGCAAATTATTTTCCAGACTCACCGAAAGCATGACACAGATGAACGAAATCATGAATGGTGAACGTGCTGCTTC
TCGTGAAACAACTATTGAGGCAGTGAAGGTAAAAAACATTCGTCAGACAACCGGCTTAAGCCAAGCGGGATTCGCTAAAT
TAATCTCTGTTAACGTTGGAACCCTTCGTAATTGGGAACAAGGAAGACGAGAACCAACAGGGCCAGCAAAAGCATTGTTA
AAGGCGATAGAGAAAGATCCGCTTCATGTATTAAAGGCGTTATCTATGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G0Q5Z0

Antitoxin

Source ID Structure
AlphaFold DB A0A077PII1

References