Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4384548..4385158 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name higB Uniprot ID A0A261RLU1
Locus tag BAU08_RS19525 Protein ID WP_066671154.1
Coordinates 4384847..4385158 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A261RLY7
Locus tag BAU08_RS19520 Protein ID WP_066671150.1
Coordinates 4384548..4384844 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU08_RS19505 4380243..4380806 - 564 WP_066671144.1 hypothetical protein -
BAU08_RS26920 4380953..4382128 + 1176 WP_082988329.1 DUF4297 domain-containing protein -
BAU08_RS19515 4382162..4383862 + 1701 WP_066671148.1 hypothetical protein -
BAU08_RS19520 4384548..4384844 - 297 WP_066671150.1 helix-turn-helix domain-containing protein Antitoxin
BAU08_RS19525 4384847..4385158 - 312 WP_066671154.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BAU08_RS19530 4385294..4387264 - 1971 WP_066671157.1 ParB N-terminal domain-containing protein -
BAU08_RS27555 4387294..4387443 - 150 WP_179283205.1 hypothetical protein -
BAU08_RS19535 4387542..4387958 - 417 WP_066671160.1 hypothetical protein -
BAU08_RS19540 4387979..4388392 - 414 WP_082988330.1 single-stranded DNA-binding protein -
BAU08_RS19545 4389397..4389651 - 255 WP_066671166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4347451..4417583 70132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11690.54 Da        Isoelectric Point: 5.8806

>T64281 WP_066671154.1 NZ_CP016171:c4385158-4384847 [Bordetella bronchialis]
MEFIETPVFTKLITALLSDEEYTGLQKLLIENPERGDLIRGGGGIRKVRYGRQGTGKSGGIRVIYYWLSEDHQIYMLVAY
PKSKKDNLTPDEIAVLCELVKEL

Download         Length: 312 bp

>T64281 NZ_CP016171:c4385158-4384847 [Bordetella bronchialis]
ATGGAATTTATCGAGACCCCGGTTTTCACGAAGCTGATTACCGCGTTGTTGTCGGATGAGGAATATACCGGGCTGCAAAA
GCTGCTGATTGAGAACCCCGAGCGAGGCGATCTCATCCGAGGCGGCGGCGGCATACGGAAGGTGCGCTACGGTCGGCAAG
GTACTGGCAAGAGCGGCGGAATTCGGGTCATCTATTACTGGCTCAGCGAAGACCACCAAATTTACATGCTGGTGGCGTAC
CCGAAATCCAAGAAGGACAACCTGACACCTGACGAGATAGCCGTGCTGTGCGAACTGGTCAAGGAGCTGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10867.54 Da        Isoelectric Point: 10.8660

>AT64281 WP_066671150.1 NZ_CP016171:c4384844-4384548 [Bordetella bronchialis]
MKKDDTLFNELQTSLKQAAAIRKGKMQPSRVFKVETVDVKATREKTHLSQTEFAEAIQVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDVAVRALRA

Download         Length: 297 bp

>AT64281 NZ_CP016171:c4384844-4384548 [Bordetella bronchialis]
ATGAAGAAGGACGACACTCTGTTTAACGAACTGCAGACCAGCCTGAAGCAAGCGGCGGCTATTCGCAAAGGGAAGATGCA
GCCCTCGCGTGTGTTCAAGGTCGAGACGGTGGACGTCAAGGCGACGCGCGAGAAGACGCACCTGTCTCAAACGGAATTCG
CAGAGGCGATTCAAGTCAGCGTCCGCACGCTGCAAAACTGGGAGCAGGGTCATCGCAATCCGACGGGGCCGGCGGTTGCT
TTGCTGAAAATCGTGGCGAGCGCTCCGGATGTCGCCGTGCGTGCGTTGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A261RLU1

Antitoxin

Source ID Structure
AlphaFold DB A0A261RLY7

References