Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2578807..2579507 Replicon chromosome
Accession NZ_CP016171
Organism Bordetella bronchialis strain AU17976

Toxin (Protein)


Gene name mqsR Uniprot ID A0A193FG99
Locus tag BAU08_RS11515 Protein ID WP_066348951.1
Coordinates 2579211..2579507 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A193FQM8
Locus tag BAU08_RS11510 Protein ID WP_066358871.1
Coordinates 2578807..2579208 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAU08_RS11500 2573982..2576096 + 2115 WP_066348949.1 flagellar biosynthesis protein FlhA -
BAU08_RS11505 2576093..2578723 + 2631 WP_066348950.1 flagellar biosynthesis protein FlhF -
BAU08_RS11510 2578807..2579208 - 402 WP_066358871.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BAU08_RS11515 2579211..2579507 - 297 WP_066348951.1 type II toxin-antitoxin system MqsR family toxin Toxin
BAU08_RS11520 2579688..2580155 - 468 WP_066348952.1 flagellar protein FlgN -
BAU08_RS11525 2580258..2580551 - 294 WP_066348953.1 flagellar biosynthesis anti-sigma factor FlgM -
BAU08_RS11530 2580744..2581451 - 708 WP_156774061.1 flagellar basal body P-ring formation protein FlgA -
BAU08_RS11535 2581815..2582222 + 408 WP_066348954.1 flagellar basal body rod protein FlgB -
BAU08_RS11540 2582242..2582658 + 417 WP_066348959.1 flagellar basal body rod protein FlgC -
BAU08_RS11545 2582709..2583407 + 699 WP_066669424.1 flagellar basal body rod modification protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA

(3-130)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10935.83 Da        Isoelectric Point: 9.1129

>T64279 WP_066348951.1 NZ_CP016171:c2579507-2579211 [Bordetella bronchialis]
MEKRTPHCRLAVVKSMVQTGQVRCTATALSGAAALGLDFSGMLDIVMRLSPSDFHKSMTTYADHKVWQDVYRPSTNMGDI
YLKLTVIDKVLIVSFKEL

Download         Length: 297 bp

>T64279 NZ_CP016171:c2579507-2579211 [Bordetella bronchialis]
ATGGAGAAACGAACCCCTCATTGCCGGTTGGCCGTAGTCAAGTCCATGGTCCAAACCGGCCAGGTGCGCTGTACCGCTAC
CGCCTTGTCTGGAGCAGCGGCCCTGGGACTGGATTTCTCGGGAATGCTGGATATCGTCATGAGGCTATCGCCATCCGACT
TTCACAAAAGCATGACGACCTATGCAGACCATAAAGTCTGGCAAGACGTCTATCGCCCGTCAACCAACATGGGCGACATA
TACCTGAAGCTGACGGTGATCGACAAGGTCCTGATCGTCTCTTTCAAGGAGCTTTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14557.78 Da        Isoelectric Point: 5.9102

>AT64279 WP_066358871.1 NZ_CP016171:c2579208-2578807 [Bordetella bronchialis]
MRCPTCGAAELRPDVRDLPYTYKSESTIIPAVAGEYCPACGESILEQAESARVSTAMLTFNKQVNSSIVDPDFILMVRRK
LALDQREAGEIFGGGVNAFSRYENGKSKPPLSLVKLLKVLDKHPELLDEVKAA

Download         Length: 402 bp

>AT64279 NZ_CP016171:c2579208-2578807 [Bordetella bronchialis]
ATGAGATGCCCAACATGCGGGGCGGCCGAACTCCGACCGGACGTGCGCGATCTGCCCTATACCTACAAGAGCGAGTCCAC
CATAATTCCCGCAGTGGCCGGCGAATACTGTCCCGCATGCGGCGAGTCCATCCTTGAACAAGCGGAATCCGCCCGTGTCA
GCACTGCAATGCTGACATTCAACAAACAGGTCAACTCATCCATCGTCGATCCAGATTTCATTTTGATGGTGCGCAGAAAG
CTGGCGCTGGATCAACGCGAAGCGGGGGAGATTTTCGGCGGGGGCGTCAATGCCTTCTCCCGCTACGAGAATGGAAAATC
GAAGCCGCCTCTTTCACTCGTCAAGTTACTGAAGGTATTGGACAAGCACCCTGAACTTCTTGATGAAGTGAAAGCAGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193FG99

Antitoxin

Source ID Structure
AlphaFold DB A0A193FQM8

References