Detailed information of TA system TA064272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 295180..295864
• Replicon: chromosome
• Accession: NZ_CP016170
• Organism: Bordetella bronchialis strain AU3182

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BAU06_RS01375
• Protein ID: WP_066343386.1
• Coordinates: 295499..295864 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A193FDA7
• Locus tag: BAU06_RS01370
• Protein ID: WP_066343383.1
• Coordinates: 295180..295506 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAU06_RS01340	290430..290837	-	408	WP_066343346.1	OB-fold domain-containing protein	-
BAU06_RS01345	290856..292145	-	1290	WP_082987903.1	CoA transferase	-
BAU06_RS01350	292156..293142	-	987	WP_066343348.1	tripartite tricarboxylate transporter substrate binding protein	-
BAU06_RS01355	293244..293678	-	435	WP_066343358.1	MaoC family dehydratase	-
BAU06_RS01360	293689..294162	-	474	WP_066343360.1	MaoC family dehydratase	-
BAU06_RS01365	294352..295125	+	774	WP_066343377.1	helix-turn-helix domain-containing protein	-
BAU06_RS01370	295180..295506	-	327	WP_066343383.1	XRE family transcriptional regulator	Antitoxin
BAU06_RS01375	295499..295864	-	366	WP_066343386.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAU06_RS01380	295967..298951	-	2985	WP_156770122.1	autotransporter domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-86)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13819.38 Da
• Isoelectric Point: 4.9078

>T64272 WP_066343386.1 NZ_CP016170:c295864-295499 [Bordetella bronchialis]
MNWDVEYTDEFASWWSSLDDSERESLDASVELLMVNGPSLGFPHSSGISSSKHRHMRELRTQHDGRPLRTLYAFDPRRCA
ILLIGGDKTGDNRWYTTHVPVADLLYDDHLMQLAKEGLIDG

Nucleotide

• Length: 366 bp

>T64272 NZ_CP016170:c295864-295499 [Bordetella bronchialis]
ATGAACTGGGATGTTGAGTACACCGATGAATTCGCGTCATGGTGGTCTTCCCTGGACGACAGTGAACGAGAATCACTGGA
TGCCAGTGTTGAACTGCTCATGGTCAACGGGCCCTCGTTGGGATTTCCACATAGCAGCGGCATAAGCAGCTCGAAACATC
GCCACATGCGGGAGCTTCGGACCCAGCACGATGGCCGCCCGCTGCGGACGCTCTACGCATTCGATCCCAGGCGGTGTGCG
ATCTTGCTTATCGGCGGCGACAAGACCGGGGACAACCGGTGGTACACGACCCACGTCCCTGTCGCTGACCTTCTATACGA
TGATCACCTCATGCAGCTGGCTAAAGAAGGGCTTATCGATGGCTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11945.80 Da
• Isoelectric Point: 8.5490

>AT64272 WP_066343383.1 NZ_CP016170:c295506-295180 [Bordetella bronchialis]
MAKKYSELRATLSPESQARAKAKAQAMMAEMPLQELRQARGLSQKMLAELLHVQQPSIAKLEKRADMYISTLRSHIEAMG
GELDVIARFPDGSVKISNFSEIDENAAA

Nucleotide

• Length: 327 bp

>AT64272 NZ_CP016170:c295506-295180 [Bordetella bronchialis]
ATGGCTAAGAAATATTCCGAACTGCGCGCAACGTTGTCGCCCGAATCGCAGGCGCGCGCCAAAGCCAAGGCGCAGGCGAT
GATGGCCGAAATGCCCTTGCAAGAGCTCCGTCAGGCACGCGGCCTATCGCAGAAGATGCTTGCCGAACTACTTCACGTGC
AGCAGCCGTCCATCGCAAAGCTGGAGAAGCGCGCCGATATGTACATCTCCACGCTGCGTAGCCATATCGAGGCCATGGGG
GGCGAGCTGGATGTGATCGCGCGTTTTCCCGATGGCTCGGTGAAGATAAGCAATTTCTCGGAAATCGACGAGAACGCAGC
AGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A193FDA7