Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 29917..30122 Replicon plasmid ISMMS_VRE11_p2
Accession NZ_CP016165
Organism Enterococcus faecium strain ISMMS_VRE_11

Toxin (Protein)


Gene name txpA Uniprot ID E3USR6
Locus tag AL025_RS15710 Protein ID WP_002295624.1
Coordinates 30000..30122 (-) Length 41 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 29917..30018 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL025_RS15685 25122..27326 + 2205 WP_025481008.1 type IA DNA topoisomerase -
AL025_RS16770 27342..27491 + 150 WP_002295632.1 hypothetical protein -
AL025_RS15690 27565..28158 + 594 WP_002287520.1 transcriptional regulator -
AL025_RS15695 28174..29073 + 900 WP_002305191.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
AL025_RS15700 29076..29561 + 486 WP_002295626.1 single-stranded DNA-binding protein -
AL025_RS15705 29583..29840 + 258 WP_002305195.1 hypothetical protein -
- 29917..30018 + 102 NuclAT_0 - Antitoxin
AL025_RS15710 30000..30122 - 123 WP_002295624.1 putative holin-like toxin Toxin
AL025_RS15715 30276..30536 + 261 WP_049055261.1 hypothetical protein -
AL025_RS15720 30626..31921 - 1296 WP_002296623.1 ISL3 family transposase -
AL025_RS15730 32490..32690 + 201 WP_002305199.1 hypothetical protein -
AL025_RS15735 32695..33132 + 438 WP_002287515.1 hypothetical protein -
AL025_RS15740 33125..33832 + 708 WP_002305202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58308 58308
- flank IS/Tn - - 30626..31921 1295


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(7-40)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4431.42 Da        Isoelectric Point: 10.3686

>T64268 WP_002295624.1 NZ_CP016165:c30122-30000 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Download         Length: 123 bp

>T64268 NZ_CP016165:c30122-30000 [Enterococcus faecium]
ATGAAAGGAGTAAGCCTTTTGTCCGCATATGAGACAATTCAAACCATTCTTGGTTTTGGTATGTTTACCATTGCTTTGAT
TAGTTTGATTGTAAATATGCTTAAAAATGACAAAAAGAAATAA

Antitoxin


Download         Length: 102 bp

>AT64268 NZ_CP016165:29917-30018 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3USR6

Antitoxin

Download structure file

References