Detailed information of TA system TA064209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 78578..79086
• Replicon: chromosome
• Accession: NZ_CP016076
• Organism: Actinoalloteichus fjordicus strain ADI127-7

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: UA74_RS00325
• Protein ID: WP_075737867.1
• Coordinates: 78578..78838 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: UA74_RS00330
• Protein ID: WP_075737869.1
• Coordinates: 78835..79086 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UA74_RS00310	74436..75659	-	1224	WP_075737861.1	hypothetical protein	-
UA74_RS00315	75941..77485	-	1545	WP_075737863.1	hypothetical protein	-
UA74_RS00320	77787..78461	+	675	WP_075737865.1	peptide-methionine (S)-S-oxide reductase MsrA	-
UA74_RS00325	78578..78838	-	261	WP_075737867.1	Txe/YoeB family addiction module toxin	Toxin
UA74_RS00330	78835..79086	-	252	WP_075737869.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
UA74_RS00335	79270..80055	-	786	WP_075763678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10483.91 Da
• Isoelectric Point: 8.8780

>T64209 WP_075737867.1 NZ_CP016076:c78838-78578 [Actinoalloteichus fjordicus]
MKLVWDESAWGDYLWWQTEDRKVLKRINDLIKDIARHGNEGMGKPEPLKHGFHGYWSRRITEEHRLVYRIADDEIRIAAC
RYHYSR

Nucleotide

• Length: 261 bp

>T64209 NZ_CP016076:c78838-78578 [Actinoalloteichus fjordicus]
ATGAAGCTGGTCTGGGACGAGTCGGCGTGGGGCGACTACCTCTGGTGGCAGACCGAGGATCGCAAGGTCCTCAAACGGAT
CAACGATCTGATCAAGGACATAGCTCGTCACGGCAATGAGGGGATGGGAAAGCCGGAGCCGCTGAAGCACGGCTTCCACG
GTTACTGGTCGCGACGGATCACCGAGGAGCATCGACTGGTCTACCGGATCGCCGACGACGAGATCCGAATCGCGGCCTGC
CGTTACCACTACAGCAGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9180.25 Da
• Isoelectric Point: 4.6104

>AT64209 WP_075737869.1 NZ_CP016076:c79086-78835 [Actinoalloteichus fjordicus]
MKTMSYSESRANYAATLDAVVADREEVVITRAGHDPVVIVSLDDYQSLKETAYLLRSPENARRLLTAIERLESGGGTQHE
LAE

Nucleotide

• Length: 252 bp

>AT64209 NZ_CP016076:c79086-78835 [Actinoalloteichus fjordicus]
ATGAAGACCATGAGTTACTCGGAGTCTCGGGCAAACTACGCTGCGACGCTCGATGCAGTGGTCGCAGACCGCGAGGAGGT
CGTGATCACCCGCGCGGGCCACGACCCGGTGGTGATCGTCTCCCTTGACGACTACCAGTCGCTCAAGGAGACCGCTTACC
TCCTGCGTAGCCCGGAGAACGCGCGACGCCTGCTCACCGCCATCGAACGGCTGGAGTCGGGCGGCGGGACGCAGCACGAA
CTCGCCGAATGA