Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 227782..228305 Replicon chromosome
Accession NZ_CP016072
Organism Staphylococcus pseudintermedius strain NA45 isolate UWMNA45

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8H9EQJ3
Locus tag A9I66_RS00965 Protein ID WP_014612815.1
Coordinates 228039..228305 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3D8YKM0
Locus tag A9I66_RS00960 Protein ID WP_014612814.1
Coordinates 227782..228039 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9I66_RS00950 224930..225424 - 495 WP_015729749.1 membrane protein -
A9I66_RS00955 225684..227588 + 1905 WP_065353959.1 triacylglycerol lipase -
A9I66_RS00960 227782..228039 + 258 WP_014612814.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A9I66_RS00965 228039..228305 + 267 WP_014612815.1 Txe/YoeB family addiction module toxin Toxin
A9I66_RS00970 228666..228767 - 102 WP_019169745.1 DUF2648 domain-containing protein -
A9I66_RS00975 228781..230274 - 1494 WP_014612817.1 malate dehydrogenase (quinone) -
A9I66_RS14330 231031..231132 + 102 Protein_198 KxYKxGKxW signal peptide domain-containing protein -
A9I66_RS14335 232565..233014 - 450 WP_201035852.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10555.15 Da        Isoelectric Point: 10.2281

>T64203 WP_014612815.1 NZ_CP016072:228039-228305 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYLRRLNHQHRVVYTVDDEKREVYI
FSAWSHYE

Download         Length: 267 bp

>T64203 NZ_CP016072:228039-228305 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTTAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9866.87 Da        Isoelectric Point: 4.1100

>AT64203 WP_014612814.1 NZ_CP016072:227782-228039 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT64203 NZ_CP016072:227782-228039 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A3D8YKM0

References