Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1744551..1745178 Replicon chromosome
Accession NZ_CP016044
Organism Edwardsiella piscicida strain S11-285

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag A9797_RS07825 Protein ID WP_015871332.1
Coordinates 1744849..1745178 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag A9797_RS07820 Protein ID WP_015871333.1
Coordinates 1744551..1744859 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9797_RS07785 1739662..1739922 + 261 WP_069578552.1 hypothetical protein -
A9797_RS07790 1740124..1741062 + 939 WP_069578554.1 helix-turn-helix domain-containing protein -
A9797_RS07795 1741059..1742441 + 1383 WP_069578555.1 replicative DNA helicase -
A9797_RS07800 1742471..1742818 + 348 WP_069578556.1 hypothetical protein -
A9797_RS07805 1742928..1743572 + 645 WP_069578557.1 DUF1367 family protein -
A9797_RS07810 1743575..1743877 + 303 WP_069578558.1 DUF1364 domain-containing protein -
A9797_RS07815 1744169..1744414 + 246 WP_069578559.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A9797_RS07820 1744551..1744859 - 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
A9797_RS07825 1744849..1745178 - 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9797_RS17950 1746586..1747154 + 569 Protein_1537 antA/AntB antirepressor family protein -
A9797_RS18885 1747138..1747347 + 210 WP_173790609.1 hypothetical protein -
A9797_RS17955 1747581..1748561 - 981 WP_071890287.1 hypothetical protein -
A9797_RS18660 1748558..1749079 - 522 WP_133176305.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1718715..1784211 65496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T64192 WP_015871332.1 NZ_CP016044:c1745178-1744849 [Edwardsiella piscicida]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T64192 NZ_CP016044:c1745178-1744849 [Edwardsiella piscicida]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACTGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT64192 WP_015871333.1 NZ_CP016044:c1744859-1744551 [Edwardsiella piscicida]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT64192 NZ_CP016044:c1744859-1744551 [Edwardsiella piscicida]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References