Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1721454..1722019 Replicon chromosome
Accession NZ_CP016044
Organism Edwardsiella piscicida strain S11-285

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A9797_RS07690 Protein ID WP_069578523.1
Coordinates 1721454..1721732 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A9797_RS07695 Protein ID WP_069578525.1
Coordinates 1721732..1722019 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9797_RS07665 1717762..1718058 - 297 WP_012848441.1 antibiotic biosynthesis monooxygenase -
A9797_RS07670 1718100..1718495 - 396 WP_015461418.1 VOC family protein -
A9797_RS17915 1718715..1718996 - 282 WP_015461419.1 ribbon-helix-helix domain-containing protein -
A9797_RS07675 1719276..1719780 - 505 Protein_1502 tyrosine-type recombinase/integrase -
A9797_RS07680 1720025..1721119 - 1095 WP_069578521.1 tyrosine-type recombinase/integrase -
A9797_RS07685 1721106..1721354 - 249 WP_015871361.1 excisionase -
A9797_RS07690 1721454..1721732 + 279 WP_069578523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A9797_RS07695 1721732..1722019 + 288 WP_069578525.1 HigA family addiction module antidote protein Antitoxin
A9797_RS18655 1722102..1722761 - 660 WP_071890273.1 hypothetical protein -
A9797_RS18875 1723271..1723720 - 450 Protein_1508 hypothetical protein -
A9797_RS18880 1723709..1724029 - 321 Protein_1509 antA/AntB antirepressor family protein -
A9797_RS07705 1724779..1726164 + 1386 WP_069578529.1 hypothetical protein -
A9797_RS07710 1726358..1726858 - 501 WP_069578531.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1718715..1784211 65496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10614.12 Da        Isoelectric Point: 7.3580

>T64191 WP_069578523.1 NZ_CP016044:1721454-1721732 [Edwardsiella piscicida]
MIKSFKHQGLKKFFLNNDSGGLEQHVVPRIRTRLTTIDAADCIDGINMPGYDLHPLKGDRKDIWSIKVSGNWRITFRFID
GDAEILNLEDYH

Download         Length: 279 bp

>T64191 NZ_CP016044:1721454-1721732 [Edwardsiella piscicida]
ATGATCAAAAGCTTCAAGCATCAGGGGTTGAAAAAATTCTTCCTCAACAATGATAGTGGCGGACTTGAGCAACACGTGGT
GCCACGGATCAGGACACGGCTGACCACCATTGATGCGGCAGACTGCATCGACGGTATCAACATGCCCGGCTACGATTTGC
ATCCACTGAAAGGCGATCGCAAAGATATTTGGTCGATAAAAGTGTCTGGCAATTGGCGTATCACTTTCCGCTTTATCGAT
GGTGATGCGGAGATCCTGAATCTGGAGGACTATCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10462.10 Da        Isoelectric Point: 7.4759

>AT64191 WP_069578525.1 NZ_CP016044:1721732-1722019 [Edwardsiella piscicida]
MKMANPAHPGEIIAETLEDMHISLRQFAKAMDIAPSTASRLISGHTSVTPEMALRLSVVLGSTAETWLKIQNHYSLNEAR
KTTDLCHLHRLVVAS

Download         Length: 288 bp

>AT64191 NZ_CP016044:1721732-1722019 [Edwardsiella piscicida]
ATGAAAATGGCTAACCCTGCGCATCCCGGCGAAATCATCGCTGAGACACTGGAGGATATGCATATCAGCCTGCGGCAGTT
CGCCAAGGCGATGGATATTGCGCCCTCCACCGCCAGCCGGCTGATCTCTGGCCACACCTCGGTTACCCCGGAAATGGCGC
TGCGCCTGTCTGTGGTGCTCGGCAGTACGGCAGAAACCTGGCTCAAGATCCAGAACCACTACAGCCTGAACGAGGCCAGA
AAAACCACTGACCTGTGCCACCTGCACCGCTTGGTAGTGGCCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References