Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1244169..1245022 Replicon chromosome
Accession NZ_CP016029
Organism Legionella pneumophila strain Pontiac

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag A9P85_RS05550 Protein ID WP_042754999.1
Coordinates 1244169..1244675 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag A9P85_RS05555 Protein ID WP_061773362.1
Coordinates 1244675..1245022 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P85_RS05530 1239256..1240065 - 810 WP_042755003.1 integrase domain-containing protein -
A9P85_RS16415 1240467..1240655 + 189 WP_136629085.1 hypothetical protein -
A9P85_RS05535 1240669..1242441 - 1773 WP_042755002.1 ATP-binding protein -
A9P85_RS05540 1242635..1242898 + 264 WP_042755001.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
A9P85_RS16070 1242977..1243143 + 167 Protein_1100 type II toxin-antitoxin system YafQ family toxin -
A9P85_RS05545 1243434..1243793 + 360 WP_042755000.1 MarR family transcriptional regulator -
A9P85_RS05550 1244169..1244675 - 507 WP_042754999.1 type II toxin-antitoxin system YhaV family toxin Toxin
A9P85_RS05555 1244675..1245022 - 348 WP_061773362.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
A9P85_RS05560 1245092..1246342 - 1251 WP_042754997.1 tyrosine-type recombinase/integrase -
A9P85_RS05565 1246825..1247691 + 867 WP_027220967.1 hypothetical protein -
A9P85_RS05570 1247795..1248154 + 360 WP_032832446.1 hypothetical protein -
A9P85_RS05575 1248199..1248573 - 375 WP_032832431.1 type II toxin-antitoxin system death-on-curing family toxin -
A9P85_RS05580 1248573..1248809 - 237 WP_027220969.1 hypothetical protein -
A9P85_RS05585 1249187..1249462 + 276 WP_027220970.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lem4/smdA / lpg1106 / ravL / ravM / lem5 / ravN / lem6 / ceg19 / lpg1124 / ravO / lpg1137 / cegC3 / lem7 / lpg1147 / lpg1148 / ravP / ravQ / lpg1158 / ravR 1142054..1364865 222811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(14-150)

Antitoxin

PrlF antitoxin

(8-105)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 19527.21 Da        Isoelectric Point: 9.5699

>T64162 WP_042754999.1 NZ_CP016029:c1244675-1244169 [Legionella pneumophila]
MVDNSIITINGWVILCHPLFLQQVEALANEVEKAKEKDPSNFHTRNSTKKLAAIAKLAFEKIPNDPAATEFRQGSTLGNN
HKHWFRAKFFQQYRLFFRYHQESKIIIYAWVNDDSSKRAYESKADAYHIFRKMLENGHPPDNWDELLKEANNTSLMKKLT
TSLDALKS

Download         Length: 507 bp

>T64162 NZ_CP016029:c1244675-1244169 [Legionella pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13166.83 Da        Isoelectric Point: 4.7483

>AT64162 WP_061773362.1 NZ_CP016029:c1245022-1244675 [Legionella pneumophila]
MARLLQTESTLTDRYQTTVPDAVRKALHLGKRDKIRYTVQSDGQVLMTRAEKEEDPVIAEFLNFIAKDIQNNPKNLTTIN
QDLVTRINSLVANVEVNLDEPLTEDEQLTENRVSR

Download         Length: 348 bp

>AT64162 NZ_CP016029:c1245022-1244675 [Legionella pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCAGGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References