Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 876588..877108 Replicon chromosome
Accession NZ_CP016019
Organism Bifidobacterium longum subsp. longum strain AH1206

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1D7UN20
Locus tag BL1206_RS03800 Protein ID WP_032746243.1
Coordinates 876588..876842 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1D7UMX7
Locus tag BL1206_RS03805 Protein ID WP_069484006.1
Coordinates 876842..877108 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL1206_RS03775 872256..873932 - 1677 WP_069483735.1 ATP-binding protein -
BL1206_RS03780 874021..874266 - 246 WP_007053507.1 hypothetical protein -
BL1206_RS03785 874538..875056 + 519 WP_065436692.1 hypothetical protein -
BL1206_RS03790 875067..875447 + 381 WP_065436691.1 hypothetical protein -
BL1206_RS03795 875530..876594 + 1065 WP_069483736.1 hypothetical protein -
BL1206_RS03800 876588..876842 - 255 WP_032746243.1 Txe/YoeB family addiction module toxin Toxin
BL1206_RS03805 876842..877108 - 267 WP_069484006.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BL1206_RS03810 877290..877670 + 381 WP_065436688.1 hypothetical protein -
BL1206_RS03815 877693..878115 + 423 WP_065436687.1 hypothetical protein -
BL1206_RS11475 878437..878712 - 276 WP_058062619.1 hypothetical protein -
BL1206_RS03825 879355..880827 - 1473 Protein_742 cell surface protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 828849..897637 68788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-76)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9918.37 Da        Isoelectric Point: 8.4862

>T64149 WP_032746243.1 NZ_CP016019:c876842-876588 [Bifidobacterium longum subsp. longum]
MLLCWTEDAWADYLYWQSQDRKTLKRVNALIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Download         Length: 255 bp

>T64149 NZ_CP016019:c876842-876588 [Bifidobacterium longum subsp. longum]
ATGCTGCTCTGCTGGACCGAAGACGCCTGGGCCGACTACCTGTACTGGCAATCCCAGGACCGGAAGACCCTCAAACGCGT
CAACGCGCTCATACGGGACATGCAGCGTACCCCGTTCGAGGGCATCGGCAAGCCCGAACCCCTCAAATGGGGCCTGTCCG
GCGCATGGTCGCGGCGCATCGACTCAGCCAACCGCATCATCTACACCGTCGCCGACGACAGGCTCTGCATCCTCTCCGCG
AAGGACCACTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9921.15 Da        Isoelectric Point: 4.4702

>AT64149 WP_069484006.1 NZ_CP016019:c877108-876842 [Bifidobacterium longum subsp. longum]
MTQAVAYSNFRANLKTYMRRVNEDADTLLVTNANPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLVEAGA

Download         Length: 267 bp

>AT64149 NZ_CP016019:c877108-876842 [Bifidobacterium longum subsp. longum]
ATGACACAGGCCGTGGCCTACAGCAATTTCAGGGCGAATCTCAAGACCTACATGCGCAGGGTCAACGAGGACGCCGACAC
CCTTCTCGTGACCAACGCGAACCCGGAGGACAACGTGGTCGTCATGAGCGCCGACGACTACGATTCGCTCATGGAGACGC
TGCGCGTCTACCAGAACCCATATCTGAGCGATAAGGTGATGCGCGGCATGGCGCAGGTCCGGCAGGGCCAGACGATGGCC
CACGACCTTGTCGAAGCGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7UN20

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7UMX7

References