Detailed information of TA system TA064116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 29927..30584
• Replicon: plasmid pCFSAN003890
• Accession: NZ_CP016013
• Organism: Salmonella enterica subsp. enterica serovar Newport strain CFSAN003890

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: A8181_RS25240
• Protein ID: WP_000270043.1
• Coordinates: 30234..30584 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A8181_RS25235
• Protein ID: WP_000124640.1
• Coordinates: 29927..30229 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8181_RS25185	25552..25980	+	429	WP_000591074.1	hypothetical protein	-
A8181_RS25190	26037..26396	+	360	WP_000422768.1	hypothetical protein	-
A8181_RS25195	26396..26842	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
A8181_RS25200	26839..27357	+	519	WP_000210756.1	nitrite reductase	-
A8181_RS25205	27357..27587	+	231	WP_000972663.1	hypothetical protein	-
A8181_RS25210	27574..28431	+	858	WP_058655996.1	hypothetical protein	-
A8181_RS25220	28662..29189	+	528	WP_001236377.1	thermonuclease family protein	-
A8181_RS25225	29247..29519	+	273	WP_001043047.1	HU family DNA-binding protein	-
A8181_RS25230	29607..29900	+	294	WP_001239997.1	chromosome segregation protein ParM	-
A8181_RS25235	29927..30229	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
A8181_RS25240	30234..30584	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8181_RS25245	30747..31295	+	549	WP_001061574.1	transcriptional regulator	-
A8181_RS25255	31636..31830	+	195	WP_000343597.1	hypothetical protein	-
A8181_RS25260	31841..32212	+	372	WP_000516916.1	hypothetical protein	-
A8181_RS25265	32205..32675	+	471	WP_001281821.1	hypothetical protein	-
A8181_RS25270	32690..33025	-	336	WP_000683476.1	hypothetical protein	-
A8181_RS25275	33122..33610	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
A8181_RS25280	33613..34110	+	498	WP_000062185.1	hypothetical protein	-
A8181_RS25290	34325..35029	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
A8181_RS25295	35094..35273	-	180	Protein_46	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..130039	130039

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T64116 WP_000270043.1 NZ_CP016013:c30584-30234 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T64116 NZ_CP016013:c30584-30234 [Salmonella enterica subsp. enterica serovar Newport]
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Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT64116 WP_000124640.1 NZ_CP016013:c30229-29927 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT64116 NZ_CP016013:c30229-29927 [Salmonella enterica subsp. enterica serovar Newport]
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Structures

Toxin

• AlphaFold DB: A0A7G8AFB9