Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3377352..3377610 Replicon chromosome
Accession NZ_CP016007
Organism Escherichia coli strain NGF1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag A9Z04_RS16265 Protein ID WP_000809168.1
Coordinates 3377352..3377504 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3377553..3377610 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9Z04_RS16245 3372597..3373310 - 714 WP_001102393.1 acidic protein MsyB -
A9Z04_RS16250 3373336..3373740 - 405 WP_000843692.1 DUF2541 family protein -
A9Z04_RS16255 3374112..3376028 + 1917 WP_000516135.1 molecular chaperone DnaK -
A9Z04_RS16260 3376117..3377247 + 1131 WP_001118464.1 molecular chaperone DnaJ -
A9Z04_RS16265 3377352..3377504 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3377553..3377610 + 58 - - Antitoxin
A9Z04_RS16270 3378119..3378880 + 762 WP_064640939.1 hypothetical protein -
A9Z04_RS16275 3378900..3380393 + 1494 Protein_3090 sulfatase-like hydrolase/transferase -
A9Z04_RS16280 3380522..3381781 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T64105 WP_000809168.1 NZ_CP016007:c3377504-3377352 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T64105 NZ_CP016007:c3377504-3377352 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT64105 NZ_CP016007:3377553-3377610 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References