Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2040991..2041212 Replicon chromosome
Accession NZ_CP015995
Organism Escherichia coli strain S51

Toxin (Protein)


Gene name ldrD Uniprot ID E0IV43
Locus tag A9K64_RS29000 Protein ID WP_000170926.1
Coordinates 2040991..2041098 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2041151..2041212 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9K64_RS10290 2036300..2037382 + 1083 WP_000804726.1 peptide chain release factor 1 -
A9K64_RS10295 2037382..2038215 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
A9K64_RS10300 2038212..2038604 + 393 WP_000200392.1 invasion regulator SirB2 -
A9K64_RS10305 2038608..2039417 + 810 WP_001257044.1 invasion regulator SirB1 -
A9K64_RS10310 2039453..2040307 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
A9K64_RS10315 2040456..2040563 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2040611..2040677 + 67 NuclAT_50 - -
- 2040611..2040677 + 67 NuclAT_50 - -
- 2040611..2040677 + 67 NuclAT_50 - -
- 2040611..2040677 + 67 NuclAT_50 - -
- 2040611..2040677 + 67 NuclAT_53 - -
- 2040611..2040677 + 67 NuclAT_53 - -
- 2040611..2040677 + 67 NuclAT_53 - -
- 2040611..2040677 + 67 NuclAT_53 - -
- 2040611..2040677 + 67 NuclAT_56 - -
- 2040611..2040677 + 67 NuclAT_56 - -
- 2040611..2040677 + 67 NuclAT_56 - -
- 2040611..2040677 + 67 NuclAT_56 - -
- 2040613..2040676 + 64 NuclAT_15 - -
- 2040613..2040676 + 64 NuclAT_15 - -
- 2040613..2040676 + 64 NuclAT_15 - -
- 2040613..2040676 + 64 NuclAT_15 - -
- 2040613..2040676 + 64 NuclAT_18 - -
- 2040613..2040676 + 64 NuclAT_18 - -
- 2040613..2040676 + 64 NuclAT_18 - -
- 2040613..2040676 + 64 NuclAT_18 - -
- 2040613..2040676 + 64 NuclAT_21 - -
- 2040613..2040676 + 64 NuclAT_21 - -
- 2040613..2040676 + 64 NuclAT_21 - -
- 2040613..2040676 + 64 NuclAT_21 - -
- 2040613..2040676 + 64 NuclAT_24 - -
- 2040613..2040676 + 64 NuclAT_24 - -
- 2040613..2040676 + 64 NuclAT_24 - -
- 2040613..2040676 + 64 NuclAT_24 - -
- 2040613..2040676 + 64 NuclAT_27 - -
- 2040613..2040676 + 64 NuclAT_27 - -
- 2040613..2040676 + 64 NuclAT_27 - -
- 2040613..2040676 + 64 NuclAT_27 - -
- 2040613..2040676 + 64 NuclAT_30 - -
- 2040613..2040676 + 64 NuclAT_30 - -
- 2040613..2040676 + 64 NuclAT_30 - -
- 2040613..2040676 + 64 NuclAT_30 - -
- 2040613..2040678 + 66 NuclAT_33 - -
- 2040613..2040678 + 66 NuclAT_33 - -
- 2040613..2040678 + 66 NuclAT_33 - -
- 2040613..2040678 + 66 NuclAT_33 - -
- 2040613..2040678 + 66 NuclAT_36 - -
- 2040613..2040678 + 66 NuclAT_36 - -
- 2040613..2040678 + 66 NuclAT_36 - -
- 2040613..2040678 + 66 NuclAT_36 - -
- 2040613..2040678 + 66 NuclAT_39 - -
- 2040613..2040678 + 66 NuclAT_39 - -
- 2040613..2040678 + 66 NuclAT_39 - -
- 2040613..2040678 + 66 NuclAT_39 - -
- 2040613..2040678 + 66 NuclAT_42 - -
- 2040613..2040678 + 66 NuclAT_42 - -
- 2040613..2040678 + 66 NuclAT_42 - -
- 2040613..2040678 + 66 NuclAT_42 - -
- 2040613..2040678 + 66 NuclAT_45 - -
- 2040613..2040678 + 66 NuclAT_45 - -
- 2040613..2040678 + 66 NuclAT_45 - -
- 2040613..2040678 + 66 NuclAT_45 - -
- 2040613..2040678 + 66 NuclAT_48 - -
- 2040613..2040678 + 66 NuclAT_48 - -
- 2040613..2040678 + 66 NuclAT_48 - -
- 2040613..2040678 + 66 NuclAT_48 - -
A9K64_RS29000 2040991..2041098 - 108 WP_000170926.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2041151..2041212 + 62 NuclAT_16 - Antitoxin
- 2041151..2041212 + 62 NuclAT_16 - Antitoxin
- 2041151..2041212 + 62 NuclAT_16 - Antitoxin
- 2041151..2041212 + 62 NuclAT_16 - Antitoxin
- 2041151..2041212 + 62 NuclAT_19 - Antitoxin
- 2041151..2041212 + 62 NuclAT_19 - Antitoxin
- 2041151..2041212 + 62 NuclAT_19 - Antitoxin
- 2041151..2041212 + 62 NuclAT_19 - Antitoxin
- 2041151..2041212 + 62 NuclAT_22 - Antitoxin
- 2041151..2041212 + 62 NuclAT_22 - Antitoxin
- 2041151..2041212 + 62 NuclAT_22 - Antitoxin
- 2041151..2041212 + 62 NuclAT_22 - Antitoxin
- 2041151..2041212 + 62 NuclAT_25 - Antitoxin
- 2041151..2041212 + 62 NuclAT_25 - Antitoxin
- 2041151..2041212 + 62 NuclAT_25 - Antitoxin
- 2041151..2041212 + 62 NuclAT_25 - Antitoxin
- 2041151..2041212 + 62 NuclAT_28 - Antitoxin
- 2041151..2041212 + 62 NuclAT_28 - Antitoxin
- 2041151..2041212 + 62 NuclAT_28 - Antitoxin
- 2041151..2041212 + 62 NuclAT_28 - Antitoxin
- 2041151..2041212 + 62 NuclAT_31 - Antitoxin
- 2041151..2041212 + 62 NuclAT_31 - Antitoxin
- 2041151..2041212 + 62 NuclAT_31 - Antitoxin
- 2041151..2041212 + 62 NuclAT_31 - Antitoxin
- 2041151..2041213 + 63 NuclAT_51 - -
- 2041151..2041213 + 63 NuclAT_51 - -
- 2041151..2041213 + 63 NuclAT_51 - -
- 2041151..2041213 + 63 NuclAT_51 - -
- 2041151..2041213 + 63 NuclAT_54 - -
- 2041151..2041213 + 63 NuclAT_54 - -
- 2041151..2041213 + 63 NuclAT_54 - -
- 2041151..2041213 + 63 NuclAT_54 - -
- 2041151..2041213 + 63 NuclAT_57 - -
- 2041151..2041213 + 63 NuclAT_57 - -
- 2041151..2041213 + 63 NuclAT_57 - -
- 2041151..2041213 + 63 NuclAT_57 - -
- 2041151..2041214 + 64 NuclAT_34 - -
- 2041151..2041214 + 64 NuclAT_34 - -
- 2041151..2041214 + 64 NuclAT_34 - -
- 2041151..2041214 + 64 NuclAT_34 - -
- 2041151..2041214 + 64 NuclAT_37 - -
- 2041151..2041214 + 64 NuclAT_37 - -
- 2041151..2041214 + 64 NuclAT_37 - -
- 2041151..2041214 + 64 NuclAT_37 - -
- 2041151..2041214 + 64 NuclAT_40 - -
- 2041151..2041214 + 64 NuclAT_40 - -
- 2041151..2041214 + 64 NuclAT_40 - -
- 2041151..2041214 + 64 NuclAT_40 - -
- 2041151..2041214 + 64 NuclAT_43 - -
- 2041151..2041214 + 64 NuclAT_43 - -
- 2041151..2041214 + 64 NuclAT_43 - -
- 2041151..2041214 + 64 NuclAT_43 - -
- 2041151..2041214 + 64 NuclAT_46 - -
- 2041151..2041214 + 64 NuclAT_46 - -
- 2041151..2041214 + 64 NuclAT_46 - -
- 2041151..2041214 + 64 NuclAT_46 - -
- 2041151..2041214 + 64 NuclAT_49 - -
- 2041151..2041214 + 64 NuclAT_49 - -
- 2041151..2041214 + 64 NuclAT_49 - -
- 2041151..2041214 + 64 NuclAT_49 - -
A9K64_RS10325 2041527..2041634 - 108 WP_000170965.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2041682..2041747 + 66 NuclAT_14 - -
- 2041682..2041747 + 66 NuclAT_14 - -
- 2041682..2041747 + 66 NuclAT_14 - -
- 2041682..2041747 + 66 NuclAT_14 - -
- 2041682..2041747 + 66 NuclAT_17 - -
- 2041682..2041747 + 66 NuclAT_17 - -
- 2041682..2041747 + 66 NuclAT_17 - -
- 2041682..2041747 + 66 NuclAT_17 - -
- 2041682..2041747 + 66 NuclAT_20 - -
- 2041682..2041747 + 66 NuclAT_20 - -
- 2041682..2041747 + 66 NuclAT_20 - -
- 2041682..2041747 + 66 NuclAT_20 - -
- 2041682..2041747 + 66 NuclAT_23 - -
- 2041682..2041747 + 66 NuclAT_23 - -
- 2041682..2041747 + 66 NuclAT_23 - -
- 2041682..2041747 + 66 NuclAT_23 - -
- 2041682..2041747 + 66 NuclAT_26 - -
- 2041682..2041747 + 66 NuclAT_26 - -
- 2041682..2041747 + 66 NuclAT_26 - -
- 2041682..2041747 + 66 NuclAT_26 - -
- 2041682..2041747 + 66 NuclAT_29 - -
- 2041682..2041747 + 66 NuclAT_29 - -
- 2041682..2041747 + 66 NuclAT_29 - -
- 2041682..2041747 + 66 NuclAT_29 - -
- 2041682..2041749 + 68 NuclAT_32 - -
- 2041682..2041749 + 68 NuclAT_32 - -
- 2041682..2041749 + 68 NuclAT_32 - -
- 2041682..2041749 + 68 NuclAT_32 - -
- 2041682..2041749 + 68 NuclAT_35 - -
- 2041682..2041749 + 68 NuclAT_35 - -
- 2041682..2041749 + 68 NuclAT_35 - -
- 2041682..2041749 + 68 NuclAT_35 - -
- 2041682..2041749 + 68 NuclAT_38 - -
- 2041682..2041749 + 68 NuclAT_38 - -
- 2041682..2041749 + 68 NuclAT_38 - -
- 2041682..2041749 + 68 NuclAT_38 - -
- 2041682..2041749 + 68 NuclAT_41 - -
- 2041682..2041749 + 68 NuclAT_41 - -
- 2041682..2041749 + 68 NuclAT_41 - -
- 2041682..2041749 + 68 NuclAT_41 - -
- 2041682..2041749 + 68 NuclAT_44 - -
- 2041682..2041749 + 68 NuclAT_44 - -
- 2041682..2041749 + 68 NuclAT_44 - -
- 2041682..2041749 + 68 NuclAT_44 - -
- 2041682..2041749 + 68 NuclAT_47 - -
- 2041682..2041749 + 68 NuclAT_47 - -
- 2041682..2041749 + 68 NuclAT_47 - -
- 2041682..2041749 + 68 NuclAT_47 - -
- 2041683..2041748 + 66 NuclAT_52 - -
- 2041683..2041748 + 66 NuclAT_52 - -
- 2041683..2041748 + 66 NuclAT_52 - -
- 2041683..2041748 + 66 NuclAT_52 - -
- 2041683..2041748 + 66 NuclAT_55 - -
- 2041683..2041748 + 66 NuclAT_55 - -
- 2041683..2041748 + 66 NuclAT_55 - -
- 2041683..2041748 + 66 NuclAT_55 - -
- 2041683..2041748 + 66 NuclAT_58 - -
- 2041683..2041748 + 66 NuclAT_58 - -
- 2041683..2041748 + 66 NuclAT_58 - -
- 2041683..2041748 + 66 NuclAT_58 - -
A9K64_RS10330 2042039..2043139 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
A9K64_RS10335 2043409..2043639 + 231 WP_001146442.1 putative cation transport regulator ChaB -
A9K64_RS10340 2043797..2044492 + 696 WP_001297117.1 glutathione-specific gamma-glutamylcyclotransferase -
A9K64_RS10345 2044536..2044889 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3983.84 Da        Isoelectric Point: 11.6501

>T64056 WP_000170926.1 NZ_CP015995:c2041098-2040991 [Escherichia coli]
MTLAKFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T64056 NZ_CP015995:c2041098-2040991 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 62 bp

>AT64056 NZ_CP015995:2041151-2041212 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y1K9

Antitoxin

Download structure file

References