Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1870731..1871233 Replicon chromosome
Accession NZ_CP015995
Organism Escherichia coli strain S51

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag A9K64_RS09275 Protein ID WP_048230341.1
Coordinates 1870979..1871233 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag A9K64_RS09270 Protein ID WP_001259255.1
Coordinates 1870731..1870982 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9K64_RS09250 1865908..1866975 - 1068 WP_048230343.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
A9K64_RS09255 1866975..1868045 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
A9K64_RS09260 1868042..1869346 - 1305 WP_048230342.1 histidinol dehydrogenase -
A9K64_RS09265 1869352..1870251 - 900 WP_000131776.1 ATP phosphoribosyltransferase -
A9K64_RS26665 1870397..1870447 - 51 WP_071952697.1 his operon leader peptide -
A9K64_RS09270 1870731..1870982 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
A9K64_RS09275 1870979..1871233 + 255 WP_048230341.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
A9K64_RS09280 1871316..1872140 + 825 WP_000754758.1 SDR family oxidoreductase -
A9K64_RS09285 1872186..1873115 + 930 WP_000803351.1 LysR family transcriptional regulator -
A9K64_RS28970 1873330..1873392 + 63 WP_010723108.1 membrane protein YoeI -
A9K64_RS09290 1873382..1874740 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
A9K64_RS09295 1874919..1875977 + 1059 WP_000492312.1 transport protein YeeE -
A9K64_RS09300 1875991..1876218 + 228 WP_000985278.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10111.52 Da        Isoelectric Point: 8.8560

>T64055 WP_048230341.1 NZ_CP015995:1870979-1871233 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFGGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T64055 NZ_CP015995:1870979-1871233 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGGAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT64055 WP_001259255.1 NZ_CP015995:1870731-1870982 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT64055 NZ_CP015995:1870731-1870982 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References