Detailed information of TA system TA064009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2546329..2547008
• Replicon: chromosome
• Accession: NZ_CP015970
• Organism: Acidipropionibacterium acidipropionici strain F3E8

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: A8L58_RS11740
• Protein ID: WP_099093033.1
• Coordinates: 2546329..2546697 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: A8L58_RS11745
• Protein ID: WP_081685418.1
• Coordinates: 2546697..2547008 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8L58_RS11705	2542174..2542557	+	384	WP_015068789.1	D-ribose pyranase	-
A8L58_RS11710	2542575..2543336	-	762	WP_062819787.1	ABC transporter permease	-
A8L58_RS11715	2543333..2544136	-	804	WP_062819788.1	ATP-binding cassette domain-containing protein	-
A8L58_RS11720	2544133..2544540	-	408	WP_126133026.1	DUF1048 domain-containing protein	-
A8L58_RS11725	2544540..2544857	-	318	WP_198401494.1	PadR family transcriptional regulator	-
A8L58_RS11730	2545019..2545936	-	918	WP_082815990.1	SDR family oxidoreductase	-
A8L58_RS11740	2546329..2546697	+	369	WP_099093033.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8L58_RS11745	2546697..2547008	+	312	WP_081685418.1	helix-turn-helix domain-containing protein	Antitoxin
A8L58_RS11750	2547171..2547590	-	420	WP_062819791.1	type II toxin-antitoxin system VapC family toxin	-
A8L58_RS11755	2547590..2547853	-	264	WP_015068797.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
A8L58_RS11760	2547975..2548241	-	267	WP_015068798.1	hypothetical protein	-
A8L58_RS11765	2548471..2548920	+	450	WP_062819792.1	CBS domain-containing protein	-
A8L58_RS11770	2548973..2550265	+	1293	WP_062820775.1	ArsB/NhaD family transporter	-
A8L58_RS11775	2550247..2550768	-	522	WP_062819793.1	MFS transporter	-
A8L58_RS11780	2550702..2551559	-	858	WP_062819794.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-113)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13922.00 Da
• Isoelectric Point: 9.4797

>T64009 WP_099093033.1 NZ_CP015970:2546329-2546697 [Acidipropionibacterium acidipropionici]
MVYTCGVWDIDAELIESWVGSLDEASRAQVIAALRILREAGPQLGRPLVDTVKASRYKNIKELRPGSSGRSELRILFAFD
PVRRAILLVAGDKAGDWERWYRKNIPRADDLYEQHLADLKRK

Nucleotide

• Length: 369 bp

>T64009 NZ_CP015970:2546329-2546697 [Acidipropionibacterium acidipropionici]
ATGGTCTATACTTGTGGTGTGTGGGATATCGACGCCGAGCTCATCGAATCCTGGGTGGGTTCCCTGGATGAGGCGTCGCG
GGCTCAGGTGATCGCCGCTCTCCGGATTCTCCGGGAGGCGGGTCCGCAACTCGGCCGCCCTCTCGTCGACACGGTGAAGG
CGTCCCGCTACAAGAACATCAAGGAGTTGCGCCCGGGCTCATCGGGACGATCGGAACTGAGAATCCTGTTCGCCTTCGAT
CCTGTCCGCAGAGCCATCCTCCTGGTAGCCGGCGACAAGGCTGGCGACTGGGAGCGCTGGTACCGCAAGAACATCCCAAG
AGCCGATGACCTGTACGAGCAGCACCTCGCAGACCTGAAACGGAAGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11627.24 Da
• Isoelectric Point: 7.0164

>AT64009 WP_081685418.1 NZ_CP015970:2546697-2547008 [Acidipropionibacterium acidipropionici]
MTMSLSLEDLEKRYPVDERLVRAAEDQMRAEVRAYKLRELRERAGLTQAQLAERIGVGQRQVSKIEHGDLDSAKLGTIRR
YLQAVGGDLAVEYVAGDQRLQVA

Nucleotide

• Length: 312 bp

>AT64009 NZ_CP015970:2546697-2547008 [Acidipropionibacterium acidipropionici]
ATGACGATGAGCCTGTCTCTGGAGGATCTGGAGAAGAGGTACCCGGTCGATGAGCGACTCGTCCGGGCCGCCGAGGATCA
GATGCGCGCCGAGGTCCGCGCCTACAAGCTCCGCGAACTGCGTGAGCGCGCCGGGCTCACCCAGGCCCAACTGGCGGAAC
GAATCGGCGTCGGACAGCGGCAGGTCTCCAAGATCGAACATGGCGACCTTGACAGCGCGAAACTCGGCACCATCCGCAGG
TACCTCCAAGCCGTCGGCGGTGACCTCGCCGTTGAGTACGTGGCTGGAGACCAGCGGCTACAAGTCGCCTGA