Detailed information of TA system TA064006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 182113..182675
• Replicon: chromosome
• Accession: NZ_CP015970
• Organism: Acidipropionibacterium acidipropionici strain F3E8

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: A8L58_RS00915
• Protein ID: WP_076692624.1
• Coordinates: 182442..182675 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: A0A3Q9CPW7
• Locus tag: A8L58_RS00910
• Protein ID: WP_062820485.1
• Coordinates: 182113..182418 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8L58_RS00890	178252..179544	-	1293	WP_015069928.1	threonine/serine exporter family protein	-
A8L58_RS00895	179552..180370	-	819	WP_015069929.1	Nif3-like dinuclear metal center hexameric protein	-
A8L58_RS00900	180495..181511	+	1017	WP_062820484.1	YdcF family protein	-
A8L58_RS00910	182113..182418	-	306	WP_062820485.1	HigA family addiction module antidote protein	Antitoxin
A8L58_RS00915	182442..182675	-	234	WP_076692624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8L58_RS00920	182731..184152	-	1422	WP_062820486.1	type I glutamate--ammonia ligase	-
A8L58_RS00925	184365..185654	+	1290	WP_126132979.1	hypothetical protein	-
A8L58_RS00930	185678..186112	+	435	WP_062820488.1	RDD family protein	-
A8L58_RS00935	186117..187250	+	1134	WP_062820489.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (19-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8578.58 Da
• Isoelectric Point: 6.6970

>T64006 WP_076692624.1 NZ_CP015970:c182675-182442 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T64006 NZ_CP015970:c182675-182442 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11069.56 Da
• Isoelectric Point: 4.6135

>AT64006 WP_062820485.1 NZ_CP015970:c182418-182113 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVEGDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT64006 NZ_CP015970:c182418-182113 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGGGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9CPW7