63963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2653988..2655231 Replicon chromosome
Accession NZ_CP015941
Organism Legionella pneumophila strain C9_S

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag A9E85_RS11715 Protein ID WP_027224015.1
Coordinates 2654293..2655231 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A1E5JNB7
Locus tag A9E85_RS11710 Protein ID WP_027224016.1
Coordinates 2653988..2654296 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9E85_RS11690 2649515..2650639 - 1125 WP_027224020.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
A9E85_RS11695 2651015..2652766 - 1752 WP_027224019.1 DUF927 domain-containing protein -
A9E85_RS11700 2652850..2653125 - 276 WP_027224018.1 helix-turn-helix domain-containing protein -
A9E85_RS11705 2653764..2653991 + 228 WP_027224017.1 helix-turn-helix transcriptional regulator -
A9E85_RS11710 2653988..2654296 + 309 WP_027224016.1 HipA N-terminal domain-containing protein Antitoxin
A9E85_RS11715 2654293..2655231 + 939 WP_027224015.1 lpg2370 family Dot/Icm T4SS effector Toxin
A9E85_RS11720 2655228..2655419 - 192 WP_032829667.1 hypothetical protein -
A9E85_RS11725 2655521..2655946 - 426 WP_027224014.1 helix-turn-helix domain-containing protein -
A9E85_RS11730 2655949..2656236 - 288 WP_027224013.1 type II toxin-antitoxin system HigB family toxin -
A9E85_RS11735 2656300..2657529 - 1230 WP_027224012.1 integrase family protein -
A9E85_RS11740 2657774..2658760 - 987 WP_042236413.1 IS30 family transposase -
A9E85_RS11745 2658942..2659730 + 789 WP_014844522.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36029.85 Da        Isoelectric Point: 9.1296

>T63963 WP_027224015.1 NZ_CP015941:2654293-2655231 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T63963 NZ_CP015941:2654293-2655231 [Legionella pneumophila]
ATGAAACACTGTCCTATTACTTATGAAAAGATAAGTGTTCAAGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGTGTAGGAAAGATGT
CTGTTCAGGGCGTCCAAAAGAAACTAAGTGCCAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTGGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACTTTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATCTAAAAAATTTTTCCTTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCATATGATTTACTTAACTCAACTATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATATTTTGCCATTGAAAAATTAGGATTAAATCAGAACGTTATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTTTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCGAGTTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.49 Da        Isoelectric Point: 4.6017

>AT63963 WP_027224016.1 NZ_CP015941:2653988-2654296 [Legionella pneumophila]
MRKAYVSVNGIRAGILEELEGKKYQFTYLNDYQGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT63963 NZ_CP015941:2653988-2654296 [Legionella pneumophila]
ATGAGAAAAGCATACGTATCAGTCAATGGCATTAGAGCTGGAATATTAGAGGAGTTAGAAGGTAAAAAATATCAATTTAC
TTACCTTAATGATTATCAGGGGGCACCTGTTTCTCTCACCATGCCGTTAACCAATAAGGTCTATGATTTTGACGTGTTTC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACGATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5JNB7

References