Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3321845..3322458 Replicon chromosome
Accession NZ_CP015936
Organism Legionella pneumophila strain C5_P

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A9E81_RS14710 Protein ID WP_070065791.1
Coordinates 3322138..3322458 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A9E81_RS14705 Protein ID WP_010948599.1
Coordinates 3321845..3322135 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9E81_RS15620 3317487..3317588 - 102 WP_077338794.1 hypothetical protein -
A9E81_RS14690 3317906..3319393 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
A9E81_RS14695 3319555..3320997 - 1443 WP_010948598.1 ATP-binding protein -
A9E81_RS14700 3321365..3321556 + 192 WP_014327021.1 hypothetical protein -
A9E81_RS14705 3321845..3322135 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
A9E81_RS14710 3322138..3322458 - 321 WP_070065791.1 hypothetical protein Toxin
A9E81_RS14715 3322663..3323166 - 504 WP_015443887.1 hypothetical protein -
A9E81_RS14720 3323276..3324322 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
A9E81_RS14725 3324626..3325588 - 963 WP_015443886.1 lytic murein transglycosylase -
A9E81_RS14730 3326118..3327296 + 1179 WP_010948604.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12350.11 Da        Isoelectric Point: 4.8949

>T63956 WP_070065791.1 NZ_CP015936:c3322458-3322138 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANCEKFDGHFKANGKRGGVRIIYYYVTPASQIRLL
LIYKKGIQDDLTTDQKKMLRQLNERW

Download         Length: 321 bp

>T63956 NZ_CP015936:c3322458-3322138 [Legionella pneumophila]
ATGATTTTTATTGAAACTCCAATTTTTACAGAAGACGTGAAGGAATTATTATCTGATGAGGAGTATGCTGAGTTTCAAGA
GTATCTTGCTGATAATCCTTTAGCTGGAGACGTAATTCAGCAAACTGGCAAACTGGCAAACTGCGAAAAGTTCGATGGTC
ATTTCAAGGCAAATGGGAAGCGAGGCGGTGTTAGAATTATTTATTATTATGTAACTCCTGCTTCACAAATAAGACTCTTA
CTTATTTATAAAAAAGGTATTCAAGATGATCTGACTACAGATCAAAAGAAAATGTTACGGCAATTAAATGAACGGTGGTA
A

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT63956 WP_010948599.1 NZ_CP015936:c3322135-3321845 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp

>AT63956 NZ_CP015936:c3322135-3321845 [Legionella pneumophila]
ATGGATAAAAAATTATTTGAACGATTATACGAAAGTATGACTCAGATGAACGAAATTATTGATGGTGAGCGTGTTCCTTC
ACGTGAGTTCGTAGTGGATGCTGTTCATGTAAAAGAAATTAGAAAAAAAACAGGCCTAACCCAAGAAAAATTTTGTCATT
TAATTGATGTAAGTATTGGAACATTAAGAAATTGGGAGCAGGGGAGAAGAGAGCCAACAGGTCCTGCAAAAGCTCTTCTT
CGCGCAATAAATAAAGATCCTGAACATGTATTAGCAGCATTAGCTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References