Detailed information of TA system TA063891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 206527..206898
• Replicon: chromosome
• Accession: NZ_CP015912
• Organism: Escherichia coli strain 210205630

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: A9C00_RS01105
• Protein ID: WP_001317028.1
• Coordinates: 206704..206898 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	206527..206705 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9C00_RS01075	202279..202452	+	174	WP_001296046.1	hypothetical protein	-
A9C00_RS01080	202482..203855	+	1374	WP_065304059.1	ATP-dependent RNA helicase DbpA	-
A9C00_RS01085	203984..204919	-	936	WP_001676520.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A9C00_RS27260	204971..206206	-	1236	WP_071961376.1	site-specific integrase	-
A9C00_RS01095	206208..206423	-	216	WP_000079604.1	excisionase XisR	-
A9C00_RS01100	206502..206711	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	206527..206705	+	179	NuclAT_0	-	Antitoxin
-	206527..206705	+	179	NuclAT_0	-	Antitoxin
-	206527..206705	+	179	NuclAT_0	-	Antitoxin
-	206527..206705	+	179	NuclAT_0	-	Antitoxin
A9C00_RS01105	206704..206898	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A9C00_RS01110	206955..207764	-	810	WP_000166319.1	recombination protein RecT	-
A9C00_RS01115	207757..210348	-	2592	WP_000105142.1	exodeoxyribonuclease VIII	-
A9C00_RS01120	210450..210725	-	276	WP_000632297.1	protein RacC	-
A9C00_RS01125	210800..210970	-	171	WP_001352098.1	conserved protein, Rac prophage	-
A9C00_RS01130	210970..211191	-	222	WP_000560225.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T63891 WP_001317028.1 NZ_CP015912:c206898-206704 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T63891 NZ_CP015912:c206898-206704 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT63891 NZ_CP015912:206527-206705 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin