Detailed information of TA system TA063871

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2773155..2773540
• Replicon: chromosome
• Accession: NZ_CP015883
• Organism: Enterococcus faecalis strain sorialis

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U3MBY2
• Locus tag: A6B47_RS13785
• Protein ID: WP_002372618.1
• Coordinates: 2773155..2773352 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2773285..2773540 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6B47_RS13765	2768632..2769264	-	633	WP_002358972.1	RloB family protein	-
A6B47_RS13770	2769273..2770568	-	1296	WP_002379013.1	AAA family ATPase	-
A6B47_RS13780	2771030..2772646	+	1617	WP_002379014.1	phosphatase PAP2/LCP family protein	-
A6B47_RS13785	2773155..2773352	+	198	WP_002372618.1	putative holin-like toxin	Toxin
-	2773285..2773540	-	256	-	-	Antitoxin
A6B47_RS13790	2773542..2777315	-	3774	WP_025193481.1	WxL domain-containing protein	-
A6B47_RS13795	2777858..2778055	+	198	WP_002368507.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7516.13 Da
• Isoelectric Point: 10.5649

>T63871 WP_002372618.1 NZ_CP015883:2773155-2773352 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 198 bp

>T63871 NZ_CP015883:2773155-2773352 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTCACAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 256 bp

>AT63871 NZ_CP015883:c2773540-2773285 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A4U3MBY2

Antitoxin