Detailed information of TA system TA063863

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2628828..2629308
• Replicon: chromosome
• Accession: NZ_CP015883
• Organism: Enterococcus faecalis strain sorialis

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: A6B47_RS13080
• Protein ID: WP_002386265.1
• Coordinates: 2628828..2628956 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2629104..2629308 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6B47_RS13055	2624357..2625309	-	953	Protein_2415	siderophore ABC transporter substrate-binding protein	-
A6B47_RS13060	2625348..2626103	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
A6B47_RS13065	2626100..2627065	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
A6B47_RS13070	2627062..2628009	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
A6B47_RS13075	2628194..2628646	+	453	WP_002378959.1	YueI family protein	-
A6B47_RS13080	2628828..2628956	-	129	WP_002386265.1	hypothetical protein	Toxin
-	2629104..2629308	+	205	-	-	Antitoxin
A6B47_RS13085	2629262..2629391	-	130	Protein_2421	putative holin-like toxin	-
A6B47_RS13090	2629554..2631824	-	2271	WP_002378960.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
A6B47_RS13095	2631995..2632495	+	501	WP_002378961.1	cysteine hydrolase	-
A6B47_RS13100	2633056..2633952	+	897	WP_087548684.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T63863 WP_002386265.1 NZ_CP015883:c2628956-2628828 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T63863 NZ_CP015883:c2628956-2628828 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 205 bp

>AT63863 NZ_CP015883:2629104-2629308 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin