Detailed information of TA system TA063843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 5126849..5127404
• Replicon: chromosome
• Accession: NZ_CP015878
• Organism: Pseudomonas citronellolis strain SJTE-3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: A9C11_RS22150
• Protein ID: WP_043270910.1
• Coordinates: 5127150..5127404 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1S1GR29
• Locus tag: A9C11_RS22145
• Protein ID: WP_043270908.1
• Coordinates: 5126849..5127121 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9C11_RS22130	5122956..5123441	+	486	WP_009623540.1	GFA family protein	-
A9C11_RS22135	5123438..5125555	-	2118	WP_064583871.1	ergothioneine biosynthesis protein EgtB	-
A9C11_RS22140	5125824..5126705	+	882	WP_064583872.1	class A beta-lactamase	-
A9C11_RS22145	5126849..5127121	+	273	WP_043270908.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
A9C11_RS22150	5127150..5127404	+	255	WP_043270910.1	Txe/YoeB family addiction module toxin	Toxin
A9C11_RS22155	5127423..5127890	-	468	WP_064583873.1	RES family NAD+ phosphorylase	-
A9C11_RS22160	5127890..5128348	-	459	WP_064583874.1	MbcA/ParS/Xre antitoxin family protein	-
A9C11_RS22165	5128818..5129177	+	360	WP_064583875.1	multidrug/spermidine efflux SMR transporter subunit MdtJ	-
A9C11_RS22170	5129171..5129500	+	330	WP_009623555.1	multidrug/spermidine efflux SMR transporter subunit MdtI	-
A9C11_RS22175	5129885..5131285	-	1401	WP_064583876.1	GABA permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9794.02 Da
• Isoelectric Point: 7.2407

>T63843 WP_043270910.1 NZ_CP015878:5127150-5127404 [Pseudomonas citronellolis]
VAFTDHGWDDYQYWKGQDPKISATLDRLIGECLRTPFSGTGKPEALKGNLSGLWSRRITREHRLVYLFEDGQLFIVQCRY
HYDG

Nucleotide

• Length: 255 bp

>T63843 NZ_CP015878:5127150-5127404 [Pseudomonas citronellolis]
GTGGCTTTCACCGATCACGGCTGGGATGACTATCAGTACTGGAAAGGCCAGGACCCGAAGATCTCCGCAACCCTGGACCG
GCTCATCGGCGAATGCCTGCGTACCCCCTTCAGCGGCACCGGCAAGCCCGAAGCGCTGAAGGGCAATCTCAGCGGGCTCT
GGTCCCGCCGCATAACCCGCGAACACCGGCTGGTCTACCTGTTCGAAGACGGCCAACTCTTCATCGTGCAATGCCGCTAC
CACTACGACGGCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10234.51 Da
• Isoelectric Point: 4.6387

>AT63843 WP_043270908.1 NZ_CP015878:5126849-5127121 [Pseudomonas citronellolis]
MQILTFSQARASLKQAMDDVCRDHEPTVITRQRGEPVVLLSLEDYNGMRETMYLLQSSANAQRLHESIEQLRVGKSVPRE
LSLSDDAEET

Nucleotide

• Length: 273 bp

>AT63843 NZ_CP015878:5126849-5127121 [Pseudomonas citronellolis]
ATGCAAATTCTGACATTCAGCCAAGCGCGAGCCAGCCTGAAACAGGCCATGGATGACGTATGCCGCGACCATGAGCCGAC
TGTCATCACCCGGCAAAGAGGCGAACCTGTGGTTCTGCTTTCGCTGGAGGACTACAACGGCATGCGCGAGACCATGTACC
TGCTGCAGTCCTCGGCCAACGCACAACGGCTGCATGAATCCATCGAGCAGTTACGAGTCGGCAAGAGCGTGCCAAGGGAA
TTGAGCCTCAGTGACGACGCAGAAGAAACGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S1GR29