Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2041148..2041743 Replicon chromosome
Accession NZ_CP015877
Organism Pseudomonas aeruginosa SJTD-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A214_RS28765 Protein ID WP_071538299.1
Coordinates 2041148..2041426 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A214_RS09415 Protein ID WP_003123432.1
Coordinates 2041438..2041743 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A214_RS09400 2036574..2037812 + 1239 WP_017148591.1 C69 family dipeptidase -
A214_RS09405 2037874..2038521 + 648 WP_003095021.1 carbonate dehydratase -
A214_RS09410 2038591..2040819 - 2229 WP_003113525.1 TonB-dependent receptor -
A214_RS28765 2041148..2041426 + 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A214_RS09415 2041438..2041743 + 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
A214_RS09420 2042079..2042456 + 378 WP_025921262.1 hypothetical protein -
A214_RS28770 2042802..2044037 + 1236 WP_158514232.1 HAD hydrolase-like protein -
A214_RS28775 2044079..2045005 + 927 WP_196664244.1 DNA-protecting protein DprA -
A214_RS28780 2045011..2045748 - 738 WP_115658289.1 HNH endonuclease -
A214_RS09430 2045828..2046217 - 390 WP_025921264.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
A214_RS28785 2046227..2046562 - 336 WP_025921265.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T63829 WP_071538299.1 NZ_CP015877:2041148-2041426 [Pseudomonas aeruginosa SJTD-1]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T63829 NZ_CP015877:2041148-2041426 [Pseudomonas aeruginosa SJTD-1]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT63829 WP_003123432.1 NZ_CP015877:2041438-2041743 [Pseudomonas aeruginosa SJTD-1]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT63829 NZ_CP015877:2041438-2041743 [Pseudomonas aeruginosa SJTD-1]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References