Detailed information of TA system TA063810

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 3741576..3741797
• Replicon: chromosome
• Accession: NZ_CP015853
• Organism: Escherichia coli strain ATCC 43889

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: A8714_RS19095
• Protein ID: WP_001295224.1
• Coordinates: 3741690..3741797 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3741576..3741641 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8714_RS19070	3737017..3737919	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
A8714_RS19075	3737930..3738913	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
A8714_RS19080	3738910..3739914	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
A8714_RS19085	3739944..3741214	-	1271	Protein_3614	transporter	-
-	3741576..3741641	-	66	NuclAT_16	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_16	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_16	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_16	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_21	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_21	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_21	-	Antitoxin
-	3741576..3741641	-	66	NuclAT_21	-	Antitoxin
A8714_RS19095	3741690..3741797	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
A8714_RS19100	3741884..3743563	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
A8714_RS19105	3743560..3743751	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
A8714_RS19110	3743748..3745319	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
A8714_RS19115	3745592..3745780	+	189	WP_001063316.1	YhjR family protein	-
A8714_RS19120	3745792..3745989	+	198	WP_000279508.1	AAA family ATPase	-
A8714_RS19125	3746008..3746544	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T63810 WP_001295224.1 NZ_CP015853:3741690-3741797 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T63810 NZ_CP015853:3741690-3741797 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT63810 NZ_CP015853:c3741641-3741576 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin