Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 2759660..2760072 | Replicon | chromosome |
Accession | NZ_CP015853 | ||
Organism | Escherichia coli strain ATCC 43889 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | A8714_RS14445 | Protein ID | WP_000132630.1 |
Coordinates | 2759731..2760072 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 2759660..2759736 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A8714_RS14435 | 2756287..2757756 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
A8714_RS14440 | 2757756..2759510 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 2759660..2759736 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 2759660..2759736 | - | 77 | NuclAT_15 | - | Antitoxin |
A8714_RS14445 | 2759731..2760072 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
A8714_RS14450 | 2760119..2761282 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
A8714_RS14455 | 2761330..2762211 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
A8714_RS14460 | 2762308..2762472 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
A8714_RS14465 | 2762649..2764061 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
A8714_RS29130 | 2764304..2764504 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 2751859..2773080 | 21221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T63806 WP_000132630.1 NZ_CP015853:2759731-2760072 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T63806 NZ_CP015853:2759731-2760072 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT63806 NZ_CP015853:c2759736-2759660 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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