Detailed information of TA system TA063798

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1522023..1522248
• Replicon: chromosome
• Accession: NZ_CP015853
• Organism: Escherichia coli strain ATCC 43889

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: A8714_RS08605
• Protein ID: WP_000813263.1
• Coordinates: 1522023..1522178 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1522190..1522248 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8714_RS08570	1517477..1518190	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
A8714_RS08575	1518328..1518524	-	197	Protein_1611	TrmB family transcriptional regulator	-
A8714_RS08580	1518811..1519629	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
A8714_RS08585	1519781..1520152	-	372	WP_000090264.1	antitermination protein	-
A8714_RS08590	1520142..1520513	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
A8714_RS08595	1520526..1521575	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
A8714_RS08600	1521577..1521855	-	279	WP_001341388.1	hypothetical protein	-
A8714_RS08605	1522023..1522178	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1522190..1522248	+	59	-	-	Antitoxin
A8714_RS08620	1522783..1523556	+	774	WP_000160654.1	alpha/beta hydrolase	-
A8714_RS08625	1523908..1524321	-	414	WP_001151233.1	DUF977 family protein	-
A8714_RS08630	1524337..1525107	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
A8714_RS08635	1525129..1525875	-	747	WP_000788745.1	ATP-binding protein	-
A8714_RS08640	1525882..1526973	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T63798 WP_000813263.1 NZ_CP015853:c1522178-1522023 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T63798 NZ_CP015853:c1522178-1522023 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT63798 NZ_CP015853:1522190-1522248 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin