Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1304278..1305073 Replicon chromosome
Accession NZ_CP015853
Organism Escherichia coli strain ATCC 43889

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag A8714_RS07380 Protein ID WP_000854914.1
Coordinates 1304278..1304652 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag A8714_RS07385 Protein ID WP_001280954.1
Coordinates 1304699..1305073 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8714_RS07340 1299282..1299773 - 492 WP_001301587.1 DUF1097 domain-containing protein -
A8714_RS07345 1299875..1300429 - 555 WP_001001917.1 molecular chaperone YcdY -
A8714_RS07350 1300453..1301190 - 738 WP_000283664.1 zinc-binding phosphatase -
A8714_RS07355 1301245..1302183 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
A8714_RS07365 1302654..1303496 - 843 WP_001280481.1 DUF4942 domain-containing protein -
A8714_RS07370 1303581..1303778 - 198 WP_000839282.1 DUF957 domain-containing protein -
A8714_RS07375 1303790..1304281 - 492 WP_000976853.1 hypothetical protein -
A8714_RS07380 1304278..1304652 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
A8714_RS07385 1304699..1305073 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A8714_RS07390 1305236..1305457 - 222 WP_001220314.1 DUF987 domain-containing protein -
A8714_RS07395 1305520..1305996 - 477 WP_001186738.1 RadC family protein -
A8714_RS07400 1306012..1306497 - 486 WP_000214398.1 antirestriction protein -
A8714_RS07405 1306588..1307406 - 819 WP_001234682.1 DUF945 domain-containing protein -
A8714_RS07415 1307746..1308815 - 1070 Protein_1404 patatin-like phospholipase family protein -
A8714_RS07420 1308812..1309717 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 1295664..1306497 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T63797 WP_000854914.1 NZ_CP015853:c1304652-1304278 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T63797 NZ_CP015853:c1304652-1304278 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT63797 WP_001280954.1 NZ_CP015853:c1305073-1304699 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT63797 NZ_CP015853:c1305073-1304699 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References