Detailed information of TA system TA063792

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 572761..572986
• Replicon: chromosome
• Accession: NZ_CP015853
• Organism: Escherichia coli strain ATCC 43889

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: A8714_RS03310
• Protein ID: WP_000813258.1
• Coordinates: 572831..572986 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	572761..572819 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8714_RS03260	567814..568056	+	243	WP_000747948.1	hypothetical protein	-
A8714_RS03265	568040..568465	+	426	WP_000693878.1	Rha family transcriptional regulator	-
A8714_RS03270	568534..569589	+	1056	WP_001356791.1	hypothetical protein	-
A8714_RS03275	569582..570043	+	462	WP_000139447.1	replication protein	-
A8714_RS03280	570077..570793	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
A8714_RS03285	570826..571107	+	282	WP_000603384.1	DNA-binding protein	-
A8714_RS03290	571104..571331	+	228	WP_000699809.1	hypothetical protein	-
A8714_RS03295	571324..571635	+	312	WP_001289673.1	hypothetical protein	-
A8714_RS03300	571763..571981	+	219	WP_000683609.1	DUF4014 family protein	-
A8714_RS03305	571983..572540	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	572761..572819	-	59	-	-	Antitoxin
A8714_RS03310	572831..572986	+	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
A8714_RS03315	573106..573450	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
A8714_RS03320	573572..573844	+	273	WP_000191871.1	hypothetical protein	-
A8714_RS03325	573846..574895	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
A8714_RS03330	574908..575213	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
A8714_RS03335	575276..575830	+	555	WP_000640035.1	DUF1133 family protein	-
A8714_RS03340	576055..576252	+	198	WP_000917763.1	hypothetical protein	-
A8714_RS03345	576387..577100	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
A8714_RS03360	577551..577982	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	512103..610432	98329

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T63792 WP_000813258.1 NZ_CP015853:572831-572986 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T63792 NZ_CP015853:572831-572986 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT63792 NZ_CP015853:c572819-572761 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin