Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4816808..4817463 Replicon chromosome
Accession NZ_CP015852
Organism Pseudomonas koreensis strain CRS05-R5

Toxin (Protein)


Gene name higB Uniprot ID A0A1A9JLM5
Locus tag A8L59_RS21475 Protein ID WP_064589096.1
Coordinates 4817119..4817463 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A031G2F6
Locus tag A8L59_RS21470 Protein ID WP_047599259.1
Coordinates 4816808..4817122 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L59_RS21445 4812332..4812850 - 519 WP_064589091.1 peptide-methionine (R)-S-oxide reductase MsrB -
A8L59_RS21450 4813002..4813712 + 711 WP_064589092.1 response regulator transcription factor -
A8L59_RS21455 4813709..4815229 + 1521 WP_064589093.1 HAMP domain-containing histidine kinase -
A8L59_RS21460 4815349..4816050 + 702 WP_064589094.1 hypothetical protein -
A8L59_RS21465 4816118..4816609 - 492 WP_064589095.1 RidA family protein -
A8L59_RS21470 4816808..4817122 - 315 WP_047599259.1 helix-turn-helix domain-containing protein Antitoxin
A8L59_RS21475 4817119..4817463 - 345 WP_064589096.1 hypothetical protein Toxin
A8L59_RS21480 4817590..4818477 - 888 WP_003227980.1 heme o synthase -
A8L59_RS21485 4818488..4818823 - 336 WP_003227981.1 cytochrome o ubiquinol oxidase subunit IV -
A8L59_RS21490 4818823..4819446 - 624 WP_003227982.1 cytochrome o ubiquinol oxidase subunit III -
A8L59_RS21495 4819450..4821477 - 2028 WP_007968380.1 cytochrome o ubiquinol oxidase subunit I -
A8L59_RS21500 4821481..4822422 - 942 WP_027612162.1 ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(47-88)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13495.43 Da        Isoelectric Point: 9.8601

>T63782 WP_064589096.1 NZ_CP015852:c4817463-4817119 [Pseudomonas koreensis]
MRTVFFETTIFTASVGRYLTDDEYRELQNYLQCNSVAGDVIPRTGGFRKLRWSDARRGKGRRGGLRVIYYWLMNDRQFWM
FAIYDKDELENLSAEQEKALKKAIEIELKKRGTP

Download         Length: 345 bp

>T63782 NZ_CP015852:c4817463-4817119 [Pseudomonas koreensis]
ATGCGAACCGTATTTTTTGAAACCACAATATTTACCGCGAGCGTTGGTCGTTATCTGACGGACGATGAGTATCGGGAGTT
GCAGAATTATCTGCAGTGCAATTCAGTGGCGGGCGACGTAATACCGCGGACTGGTGGCTTCCGAAAATTACGTTGGTCTG
ATGCCCGACGAGGCAAAGGGCGACGAGGTGGCTTGCGAGTCATCTACTATTGGCTTATGAATGATCGTCAGTTTTGGATG
TTTGCGATATATGACAAAGATGAGCTTGAAAATCTGTCCGCCGAGCAAGAGAAGGCGCTCAAAAAAGCCATTGAAATAGA
GTTGAAAAAACGAGGTACCCCATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11836.82 Da        Isoelectric Point: 10.2426

>AT63782 WP_047599259.1 NZ_CP015852:c4817122-4816808 [Pseudomonas koreensis]
MKKRDLFAELMQGVEEMAAHREGKITLRNTVVEDKPVPEVGAQEIVALREKLHMSQAVFAKRIRTSPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVERLGAV

Download         Length: 315 bp

>AT63782 NZ_CP015852:c4817122-4816808 [Pseudomonas koreensis]
ATGAAAAAGCGCGACCTGTTTGCGGAATTGATGCAGGGCGTTGAAGAGATGGCCGCCCATCGCGAAGGTAAAATCACGTT
GCGCAATACGGTCGTCGAGGACAAGCCGGTTCCCGAGGTTGGTGCACAGGAGATCGTTGCACTGCGTGAAAAATTACACA
TGTCACAGGCGGTATTTGCAAAGCGAATCAGGACCAGCCCGAGTACATTGAGAAATTGGGAGCAGGAGAAGTCAAAACCC
AATGCTCAGGCGGCACTGTTGATCCGCTTGGTGGAGAAATTCCCTGATATGGTTGAGCGATTAGGCGCTGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9JLM5

Antitoxin

Source ID Structure
AlphaFold DB A0A031G2F6

References