Detailed information of TA system TA063773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 626780..627384
• Replicon: chromosome
• Accession: NZ_CP015848
• Organism: Magnetospirillum sp. ME-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: WV31_RS02815
• Protein ID: WP_085375437.1
• Coordinates: 627058..627384 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: WV31_RS02810
• Protein ID: WP_008620724.1
• Coordinates: 626780..627061 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WV31_RS02790	622881..623342	+	462	WP_085372162.1	transcriptional regulator NrdR	-
WV31_RS02795	623460..625556	+	2097	WP_085372163.1	PAS domain-containing protein	-
WV31_RS02800	625578..625982	+	405	WP_085372164.1	hemerythrin family protein	-
WV31_RS02805	626225..626620	+	396	WP_085372165.1	transcriptional repressor	-
WV31_RS02810	626780..627061	-	282	WP_008620724.1	helix-turn-helix domain-containing protein	Antitoxin
WV31_RS02815	627058..627384	-	327	WP_085375437.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WV31_RS02820	627726..628190	+	465	WP_085372166.1	DUF1465 family protein	-
WV31_RS02825	628318..629076	+	759	WP_085372167.1	EAL domain-containing protein	-
WV31_RS02830	629194..629745	-	552	WP_085372168.1	recombinase family protein	-
WV31_RS21380	629859..630545	-	687	WP_145980715.1	hypothetical protein	-
WV31_RS02835	630780..631130	+	351	WP_085372169.1	hypothetical protein	-
WV31_RS02840	631315..631893	+	579	WP_145980716.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	615637..632762	17125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-82)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12235.56 Da
• Isoelectric Point: 10.5339

>T63773 WP_085375437.1 NZ_CP015848:c627384-627058 [Magnetospirillum sp. ME-1]
MEWKVETLNEIVDAEIAVLPKDMQARFLRIAGMIESAGLEGMGHPHVKPLEGKLWEMRLMGRDGIARALYVTVTGRRVVV
VRAFVKKTQKTPRQEIELALARAKEILK

Nucleotide

• Length: 327 bp

>T63773 NZ_CP015848:c627384-627058 [Magnetospirillum sp. ME-1]
ATGGAATGGAAGGTCGAAACCCTCAACGAAATCGTGGACGCGGAAATCGCTGTCTTGCCCAAGGATATGCAGGCCCGTTT
TCTGCGGATAGCCGGGATGATTGAGTCTGCTGGGTTGGAAGGTATGGGGCATCCTCATGTGAAGCCGCTTGAGGGCAAGT
TATGGGAGATGCGGCTAATGGGCCGCGACGGCATCGCCCGTGCCCTCTATGTGACCGTCACTGGTCGGCGGGTCGTGGTA
GTGCGGGCCTTTGTAAAAAAGACTCAGAAGACGCCTCGCCAGGAGATTGAACTCGCATTGGCTCGGGCCAAGGAGATTTT
GAAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10131.62 Da
• Isoelectric Point: 10.5386

>AT63773 WP_008620724.1 NZ_CP015848:c627061-626780 [Magnetospirillum sp. ME-1]
MTSLNDLKAKMLADPEVKAEYDRLAPEFEIAETLIRARQRAGLSQAEVAKRMGTTQSVVARLESGRSLPSSTSLARYAAA
TGSRLRVELLPGR

Nucleotide

• Length: 282 bp

>AT63773 NZ_CP015848:c627061-626780 [Magnetospirillum sp. ME-1]
ATGACCAGCCTGAATGATCTCAAGGCTAAAATGCTGGCTGATCCCGAGGTTAAGGCCGAATATGACCGTCTCGCTCCCGA
GTTCGAGATTGCGGAAACCCTTATCCGTGCCCGGCAACGGGCGGGTCTATCTCAGGCCGAAGTCGCAAAACGGATGGGCA
CCACCCAGTCCGTGGTTGCACGGCTGGAAAGTGGCCGTTCCCTTCCTTCATCTACTTCACTGGCACGCTACGCCGCCGCC
ACAGGAAGCCGCCTTCGTGTTGAGCTTCTTCCTGGTCGATGA