63723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5584074..5584486 Replicon chromosome
Accession NZ_CP015843
Organism Escherichia coli O157:H7 strain FRIK2455

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag A8V32_RS30080 Protein ID WP_000132630.1
Coordinates 5584074..5584415 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5584410..5584486 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8V32_RS32105 5579642..5579842 + 201 WP_001310455.1 hypothetical protein -
A8V32_RS30055 5580085..5581497 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
A8V32_RS30065 5581674..5581838 + 165 WP_000394274.1 DUF1127 domain-containing protein -
A8V32_RS30070 5581935..5582816 + 882 WP_001304007.1 DUF262 domain-containing protein -
A8V32_RS30075 5582864..5584027 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
A8V32_RS30080 5584074..5584415 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5584410..5584486 + 77 NuclAT_14 - Antitoxin
- 5584410..5584486 + 77 NuclAT_14 - Antitoxin
- 5584410..5584486 + 77 NuclAT_14 - Antitoxin
- 5584410..5584486 + 77 NuclAT_14 - Antitoxin
- 5584410..5584486 + 77 NuclAT_15 - Antitoxin
- 5584410..5584486 + 77 NuclAT_15 - Antitoxin
- 5584410..5584486 + 77 NuclAT_15 - Antitoxin
- 5584410..5584486 + 77 NuclAT_15 - Antitoxin
A8V32_RS30085 5584636..5586389 - 1754 Protein_5462 restriction endonuclease subunit S -
A8V32_RS30090 5586389..5587858 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5573567..5592286 18719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T63723 WP_000132630.1 NZ_CP015843:c5584415-5584074 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T63723 NZ_CP015843:c5584415-5584074 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT63723 NZ_CP015843:5584410-5584486 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References