Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 279707..280246 Replicon chromosome
Accession NZ_CP015842
Organism Escherichia coli O157:H7 strain FRIK2533

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag A8V31_RS01345 Protein ID WP_001303998.1
Coordinates 279707..279967 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag A8V31_RS01350 Protein ID WP_000729705.1
Coordinates 279986..280246 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8V31_RS01330 277390..277968 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
A8V31_RS01335 278073..278840 + 768 WP_001301698.1 class II glutamine amidotransferase -
A8V31_RS01340 278811..279551 - 741 WP_001225679.1 murein L,D-transpeptidase -
A8V31_RS01345 279707..279967 - 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
A8V31_RS01350 279986..280246 - 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
A8V31_RS01355 280432..281205 + 774 WP_000543891.1 C40 family peptidase -
A8V31_RS01360 281381..281878 + 498 Protein_247 REP-associated tyrosine transposase RayT -
A8V31_RS01365 282023..283735 - 1713 Protein_248 flagellar biosynthesis protein FlhA -
A8V31_RS01370 283707..284492 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-85)

Antitoxin

(1-85)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T63644 WP_001303998.1 NZ_CP015842:c279967-279707 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T63644 NZ_CP015842:c279967-279707 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT63644 WP_000729705.1 NZ_CP015842:c280246-279986 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT63644 NZ_CP015842:c280246-279986 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References