63577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2649027..2649498 Replicon chromosome
Accession NZ_CP015832
Organism Escherichia coli O157 strain 180-PT54

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag A8L39_RS13780 Protein ID WP_001303511.1
Coordinates 2649027..2649305 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag A8L39_RS13785 Protein ID WP_001302048.1
Coordinates 2649307..2649498 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L39_RS33705 2644033..2644217 - 185 Protein_2624 DUF3596 domain-containing protein -
A8L39_RS13745 2644252..2644503 - 252 WP_000005552.1 excisionase family protein -
A8L39_RS13750 2644576..2647047 - 2472 WP_000048458.1 exonuclease -
A8L39_RS13755 2647140..2647331 - 192 WP_001090200.1 DUF1482 family protein -
A8L39_RS13760 2647328..2647516 - 189 WP_000449192.1 cell division inhibition protein DicB -
A8L39_RS13765 2648085..2648303 - 219 WP_001171930.1 hypothetical protein -
A8L39_RS13770 2648375..2648674 - 300 WP_072143447.1 hypothetical protein -
A8L39_RS13780 2649027..2649305 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8L39_RS13785 2649307..2649498 - 192 WP_001302048.1 hypothetical protein Antitoxin
A8L39_RS32400 2649519..2649890 - 372 WP_001169686.1 hypothetical protein -
A8L39_RS13795 2649988..2650290 + 303 WP_000172738.1 transcriptional regulator -
A8L39_RS13800 2650287..2650712 + 426 WP_000693943.1 Rha family transcriptional regulator -
A8L39_RS13805 2650735..2651697 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
A8L39_RS13810 2651704..2652444 + 741 WP_000788938.1 ATP-binding protein -
A8L39_RS13820 2652470..2653239 + 770 Protein_2638 DUF1627 domain-containing protein -
A8L39_RS13825 2653255..2653650 + 396 WP_001118159.1 DUF977 family protein -
A8L39_RS13830 2653707..2654291 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2641866..2739931 98065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T63577 WP_001303511.1 NZ_CP015832:c2649305-2649027 [Escherichia coli O157]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T63577 NZ_CP015832:c2649305-2649027 [Escherichia coli O157]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT63577 WP_001302048.1 NZ_CP015832:c2649498-2649307 [Escherichia coli O157]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT63577 NZ_CP015832:c2649498-2649307 [Escherichia coli O157]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References