Detailed information of TA system TA063560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 314684..314905
• Replicon: chromosome
• Accession: NZ_CP015832
• Organism: Escherichia coli O157 strain 180-PT54

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: A8L39_RS32040
• Protein ID: WP_001295224.1
• Coordinates: 314798..314905 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	314684..314749 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8L39_RS01620	310124..311026	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
A8L39_RS01625	311037..312020	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
A8L39_RS01630	312017..313021	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
A8L39_RS01635	313051..314322	-	1272	WP_001301684.1	amino acid permease	-
-	314684..314749	-	66	NuclAT_16	-	Antitoxin
-	314684..314749	-	66	NuclAT_16	-	Antitoxin
-	314684..314749	-	66	NuclAT_16	-	Antitoxin
-	314684..314749	-	66	NuclAT_16	-	Antitoxin
-	314684..314749	-	66	NuclAT_21	-	Antitoxin
-	314684..314749	-	66	NuclAT_21	-	Antitoxin
-	314684..314749	-	66	NuclAT_21	-	Antitoxin
-	314684..314749	-	66	NuclAT_21	-	Antitoxin
A8L39_RS32040	314798..314905	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
A8L39_RS01650	314992..316671	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
A8L39_RS01655	316668..316859	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
A8L39_RS01660	316856..318427	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
A8L39_RS01665	318700..318888	+	189	WP_001063316.1	YhjR family protein	-
A8L39_RS01670	318900..319097	+	198	WP_000279508.1	AAA family ATPase	-
A8L39_RS01675	319116..319652	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T63560 WP_001295224.1 NZ_CP015832:314798-314905 [Escherichia coli O157]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T63560 NZ_CP015832:314798-314905 [Escherichia coli O157]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT63560 NZ_CP015832:c314749-314684 [Escherichia coli O157]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin