Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ibs-sib/- |
| Location | 3194723..3194865 | Replicon | chromosome |
| Accession | NC_000913 | ||
| Organism | Escherichia coli str. K-12 substr. MG1655 | ||
| T1TAdb ID | TA07165 | ||
Toxin (Protein)
| Gene name | ibs | Uniprot ID | C1P616 |
| Locus tag | b4664 | Protein ID | YP_002791256.1 |
| Coordinates | 3194766..3194825 (+) | Length | 20 a.a. |
Antitoxin (RNA)
| Gene name | sib | ||
| Locus tag | b4447 | ||
| Coordinates | 3194723..3194872 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 20 a.a. Molecular weight: 2150.84 Da Isoelectric Point: 8.7571
>T6356 YP_002791256.1 NC_000913:3194766-3194825 [Escherichia coli str. K-12 substr. MG1655]
MMKLVIILIVLLLVSFAAY
MMKLVIILIVLLLVSFAAY
Download Length: 60 bp
>T6356 NC_000913:3194766-3194825 [Escherichia coli str. K-12 substr. MG1655]
ATGATGAAGCTCGTCATCATACTGATTGTGTTGTTACTCGTAAGTTTCGCAGCTTATTAA
ATGATGAAGCTCGTCATCATACTGATTGTGTTGTTACTCGTAAGTTTCGCAGCTTATTAA
Antitoxin
Download Length: 150 bp
>AT6356 NC_000913:c3194872-3194723 [Escherichia coli str. K-12 substr. MG1655]
TAAAGGAACAAGGGTGAGGGAGGATTTCTCCCCCCTCTGATTGGCTGTTAATAAGCTGCGAAACTTACGAGTAACAACAC
AATCAGTATGATGACGAGCTTCATCATAACCCTTTCCTTCTGTAAGGCCCCCTTCTTCGGGAGGGGCTTT
TAAAGGAACAAGGGTGAGGGAGGATTTCTCCCCCCTCTGATTGGCTGTTAATAAGCTGCGAAACTTACGAGTAACAACAC
AATCAGTATGATGACGAGCTTCATCATAACCCTTTCCTTCTGTAAGGCCCCCTTCTTCGGGAGGGGCTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Molecular Microbiology 70(5):1076-93. [PubMed:18710431]
(2) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]