Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ibs-sib/- |
| Location | 3056849..3056988 | Replicon | chromosome |
| Accession | NC_000913 | ||
| Organism | Escherichia coli str. K-12 substr. MG1655 | ||
| T1TAdb ID | TA07164 | ||
Toxin (Protein)
| Gene name | ibs | Uniprot ID | C1P615 |
| Locus tag | b4665 | Protein ID | YP_002791255.1 |
| Coordinates | 3056890..3056949 (-) | Length | 20 a.a. |
Antitoxin (RNA)
| Gene name | sib | ||
| Locus tag | b4446 | ||
| Coordinates | 3056844..3056988 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| b2907 | 3052340..3053518 | - | 1179 | NP_417383.1 | 2-octaprenyl-6-methoxyphenol 4-hydroxylase | - |
| b2908 | 3053515..3054840 | - | 1326 | NP_417384.1 | Xaa-Pro aminopeptidase | - |
| b2909 | 3054866..3055444 | - | 579 | NP_417385.4 | PF03695 family protein YgfB | - |
| b2910 | 3055612..3055941 | + | 330 | NP_417386.1 | cell division protein ZapA | - |
| b2912 | 3056241..3056789 | + | 549 | NP_417387.3 | putative 5-formyltetrahydrofolate cyclo-ligase | - |
| - | 3056844..3056988 | + | 145 | - | - | Antitoxin |
| b4665 | 3056890..3056949 | - | 60 | YP_002791255.1 | toxic peptide IbsC | Toxin |
| b2913 | 3057178..3058410 | - | 1233 | NP_417388.1 | phosphoglycerate dehydrogenase | - |
| b2914 | 3058666..3059325 | - | 660 | NP_417389.1 | ribose-5-phosphate isomerase A | - |
| b2916 | 3059753..3060646 | + | 894 | NP_417391.1 | DNA-binding transcriptional dual regulator ArgP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 20 a.a. Molecular weight: 2208.88 Da Isoelectric Point: 8.7990
>T6355 YP_002791255.1 NC_000913:c3056949-3056890 [Escherichia coli str. K-12 substr. MG1655]
MMRLVIILIVLLLISFSAY
MMRLVIILIVLLLISFSAY
Download Length: 60 bp
>T6355 NC_000913:c3056949-3056890 [Escherichia coli str. K-12 substr. MG1655]
ATGATGCGACTTGTCATCATACTGATTGTACTGTTACTCATAAGTTTCAGCGCTTATTAA
ATGATGCGACTTGTCATCATACTGATTGTACTGTTACTCATAAGTTTCAGCGCTTATTAA
Antitoxin
Download Length: 145 bp
>AT6355 NC_000913:3056844-3056988 [Escherichia coli str. K-12 substr. MG1655]
AGTGAGTAAGGGTAAGGGAGGATTGCTCCTCCCCTGAGACTGACTGTTAATAAGCGCTGAAACTTATGAGTAACAGTACA
ATCAGTATGATGACAAGTCGCATCATAACCCTTCTCCTTCAAGCCCTCGCTTCGGTGAGGGCTTT
AGTGAGTAAGGGTAAGGGAGGATTGCTCCTCCCCTGAGACTGACTGTTAATAAGCGCTGAAACTTATGAGTAACAGTACA
ATCAGTATGATGACAAGTCGCATCATAACCCTTCTCCTTCAAGCCCTCGCTTCGGTGAGGGCTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Molecular Microbiology 70(5):1076-93. [PubMed:18710431]
(2) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]