Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ibs-sib/- |
| Location | 2153309..2153451 | Replicon | chromosome |
| Accession | NC_000913 | ||
| Organism | Escherichia coli str. K-12 substr. MG1655 | ||
| T1TAdb ID | TA07162 | ||
Toxin (Protein)
| Gene name | ibs | Uniprot ID | C1P607 |
| Locus tag | b4667 | Protein ID | YP_002791247.1 |
| Coordinates | 2153349..2153408 (-) | Length | 20 a.a. |
Antitoxin (RNA)
| Gene name | sib | ||
| Locus tag | b4436 | ||
| Coordinates | 2153303..2153451 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| b2070 | 2149039..2150985 | - | 1947 | NP_416574.1 | putative serine/threonine-protein kinase YegI | - |
| b2071 | 2151185..2151646 | + | 462 | NP_416575.1 | DUF2314 domain-containing protein YegJ | - |
| b2072 | 2151711..2152472 | - | 762 | NP_416576.1 | protein-serine/threonine phosphatase PphC | - |
| b2073 | 2152469..2153128 | - | 660 | NP_416577.1 | IPR002035 domain-containing protein YegL | - |
| - | 2153303..2153451 | + | 149 | - | - | Antitoxin |
| b4667 | 2153349..2153408 | - | 60 | YP_002791247.1 | toxic peptide IbsA | Toxin |
| b4668 | 2153681..2153737 | - | 57 | YP_002791248.1 | putative toxic peptide IbsB | - |
| b2074 | 2154016..2155263 | + | 1248 | NP_416578.2 | multidrug efflux pump membrane fusion protein MdtA | - |
| b2075 | 2155263..2158385 | + | 3123 | NP_416579.1 | multidrug efflux pump RND permease subunit MdtB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 20 a.a. Molecular weight: 2231.87 Da Isoelectric Point: 8.7797
>T6353 YP_002791247.1 NC_000913:c2153408-2153349 [Escherichia coli str. K-12 substr. MG1655]
MMKHVIILVILLVISFQAY
MMKHVIILVILLVISFQAY
Download Length: 60 bp
>T6353 NC_000913:c2153408-2153349 [Escherichia coli str. K-12 substr. MG1655]
ATGATGAAGCACGTCATCATACTGGTGATACTCTTAGTGATTAGCTTCCAGGCTTACTAA
ATGATGAAGCACGTCATCATACTGGTGATACTCTTAGTGATTAGCTTCCAGGCTTACTAA
Antitoxin
Download Length: 149 bp
>AT6353 NC_000913:2153303-2153451 [Escherichia coli str. K-12 substr. MG1655]
TCAGGAGTGAGGGTTAGGGAGAGGTTTCCCCCTCCCCCTGGTGTTCTTAGTAAGCCTGGAAGCTAATCACTAAGAGTATC
ACCAGTATGATGACGTGCTTCATCATAACCCTTTCCTTATTAAAAGCCCTCTTCTCCGGGAGAGGCTTT
TCAGGAGTGAGGGTTAGGGAGAGGTTTCCCCCTCCCCCTGGTGTTCTTAGTAAGCCTGGAAGCTAATCACTAAGAGTATC
ACCAGTATGATGACGTGCTTCATCATAACCCTTTCCTTATTAAAAGCCCTCTTCTCCGGGAGAGGCTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Elizabeth M Fozo et al. (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Molecular Microbiology 70(5):1076-93. [PubMed:18710431]
(2) Elizabeth M Fozo et al. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Research 38(11):3743-59. [PubMed:20156992]