63493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2462379..2462896 Replicon chromosome
Accession NZ_CP015817
Organism Staphylococcus aureus strain FORC_039

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FORC39_RS12850 Protein ID WP_000113262.1
Coordinates 2462379..2462645 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FORC39_RS12855 Protein ID WP_000584499.1
Coordinates 2462645..2462896 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC39_RS12820 2457805..2458341 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FORC39_RS12825 2458574..2459398 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FORC39_RS12830 2459615..2459797 - 183 WP_000230294.1 hypothetical protein -
FORC39_RS12835 2459881..2460348 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FORC39_RS12840 2460534..2462084 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FORC39_RS12845 2462273..2462344 - 72 Protein_2385 hypothetical protein -
FORC39_RS12850 2462379..2462645 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FORC39_RS12855 2462645..2462896 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC39_RS12860 2463061..2463162 - 102 WP_001791744.1 hypothetical protein -
FORC39_RS12865 2463169..2463768 - 600 WP_000162813.1 DsbA family protein -
FORC39_RS12870 2463787..2464149 - 363 WP_000819843.1 DUF4467 domain-containing protein -
FORC39_RS12875 2464404..2465654 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FORC39_RS12880 2465751..2466482 - 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
FORC39_RS12885 2466479..2467198 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T63493 WP_000113262.1 NZ_CP015817:c2462645-2462379 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T63493 NZ_CP015817:c2462645-2462379 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT63493 WP_000584499.1 NZ_CP015817:c2462896-2462645 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT63493 NZ_CP015817:c2462896-2462645 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References