Detailed information of TA system TA063481

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 917825..918163
• Replicon: chromosome
• Accession: NZ_CP015817
• Organism: Staphylococcus aureus strain FORC_039

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FORC39_RS04715
• Protein ID: WP_011447039.1
• Coordinates: 917825..918001 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	917989..918163 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC39_RS04695	913060..916845	+	3786	WP_000582178.1	hypothetical protein	-
FORC39_RS04700	916835..916987	+	153	WP_001153681.1	hypothetical protein	-
FORC39_RS04705	917034..917321	+	288	WP_001040261.1	hypothetical protein	-
FORC39_RS04710	917379..917675	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
FORC39_RS04715	917825..918001	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	917989..918163	-	175	-	-	Antitoxin
FORC39_RS04725	918213..918467	+	255	WP_000611512.1	phage holin	-
FORC39_RS04730	918479..919234	+	756	Protein_882	CHAP domain-containing protein	-
FORC39_RS04735	919425..919916	+	492	WP_000920038.1	staphylokinase	-
FORC39_RS04755	920567..920902	+	336	Protein_884	SH3 domain-containing protein	-
FORC39_RS04760	921413..921763	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
FORC39_RS04765	921816..922076	-	261	WP_001791826.1	hypothetical protein	-
FORC39_RS04775	922387..922566	-	180	WP_000669791.1	hypothetical protein	-
FORC39_RS04780	922888..923138	-	251	Protein_888	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	880411..921763	41352

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T63481 WP_011447039.1 NZ_CP015817:917825-918001 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T63481 NZ_CP015817:917825-918001 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT63481 NZ_CP015817:c918163-917989 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGATGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin