63318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3682760..3683274 Replicon chromosome
Accession NZ_CP015726
Organism Streptomyces sp. RTd22

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag A7B19_RS15070 Protein ID WP_063734433.1
Coordinates 3683020..3683274 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag A7B19_RS15065 Protein ID WP_063734434.1
Coordinates 3682760..3683023 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7B19_RS47540 3678219..3678481 + 263 Protein_3072 restriction endonuclease -
A7B19_RS15050 3678706..3679248 - 543 WP_063734436.1 winged helix-turn-helix domain-containing protein -
A7B19_RS15055 3679306..3680208 + 903 WP_063734435.1 S41 family peptidase -
A7B19_RS15060 3680938..3681525 - 588 WP_159073630.1 pentapeptide repeat-containing protein -
A7B19_RS50375 3681560..3681886 - 327 WP_159073629.1 hypothetical protein -
A7B19_RS15065 3682760..3683023 + 264 WP_063734434.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A7B19_RS15070 3683020..3683274 + 255 WP_063734433.1 Txe/YoeB family addiction module toxin Toxin
A7B19_RS15075 3684006..3684911 - 906 WP_063734432.1 LysR family transcriptional regulator -
A7B19_RS15080 3685081..3685974 + 894 WP_063734431.1 SDR family NAD(P)-dependent oxidoreductase -
A7B19_RS47545 3686369..3687756 + 1388 Protein_3081 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10094.43 Da        Isoelectric Point: 8.4059

>T63318 WP_063734433.1 NZ_CP015726:3683020-3683274 [Streptomyces sp. RTd22]
VRISFTSHAWEDYTYWAENDRKIVKRINKLIDDTVRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPIDDELIIVQA
RYHY

Download         Length: 255 bp

>T63318 NZ_CP015726:3683020-3683274 [Streptomyces sp. RTd22]
GTGAGGATCTCGTTCACGTCACACGCCTGGGAGGACTACACCTACTGGGCCGAGAACGACCGCAAGATCGTCAAACGCAT
CAACAAGCTGATCGACGACACGGTGCGCGACCCCTTCAAGGGCATCGGCAAACCGGAGCCCCTGAAGGGCGACCTCTCGG
GATACTGGTCCCGGCGCATCGACGACACACACCGGCTCGTGTACAAGCCGATAGACGACGAGTTGATCATCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9807.82 Da        Isoelectric Point: 4.5172

>AT63318 WP_063734434.1 NZ_CP015726:3682760-3683023 [Streptomyces sp. RTd22]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTSWTETVHLLRSPKNARRLLDSIAEAEDGQTQQRELI
DPDAEHA

Download         Length: 264 bp

>AT63318 NZ_CP015726:3682760-3683023 [Streptomyces sp. RTd22]
ATGTCCATCACCGCCAGCGAGGCACGCCAGAACCTGTTCCCACTGATCGAGCAGGTCAACGAGGACCACGCCCCGGTTCA
CATCACCTCCCGCAAAGGGAACGCCGTCCTGATGTCCGAAGAGGACTTCACCTCCTGGACGGAGACAGTGCACCTCCTCC
GCTCCCCCAAGAACGCCCGCCGTCTGCTCGACTCCATCGCCGAGGCCGAGGACGGCCAGACTCAGCAGCGTGAGCTGATC
GACCCCGACGCGGAGCATGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References