Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2574545..2574729 Replicon chromosome
Accession NZ_CP015646
Organism Staphylococcus aureus strain 08-02300

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag A7327_RS12985 Protein ID WP_000482652.1
Coordinates 2574622..2574729 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2574545..2574605 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7327_RS12965 2570000..2570167 - 168 WP_001789205.1 hypothetical protein -
A7327_RS12970 2570398..2572131 - 1734 WP_049307645.1 ABC transporter ATP-binding protein/permease -
A7327_RS12975 2572156..2573919 - 1764 WP_001064837.1 ABC transporter ATP-binding protein/permease -
- 2574545..2574605 + 61 - - Antitoxin
A7327_RS12985 2574622..2574729 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
A7327_RS12990 2574863..2575249 - 387 WP_000779357.1 flippase GtxA -
A7327_RS12995 2575517..2576659 + 1143 WP_001176863.1 glycerate kinase -
A7327_RS13000 2576719..2577378 + 660 WP_000831298.1 membrane protein -
A7327_RS13005 2577560..2578771 + 1212 WP_001191922.1 multidrug effflux MFS transporter -
A7327_RS13010 2578894..2579367 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T63314 WP_000482652.1 NZ_CP015646:c2574729-2574622 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T63314 NZ_CP015646:c2574729-2574622 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT63314 NZ_CP015646:2574545-2574605 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References