Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2549238..2549755 Replicon chromosome
Accession NZ_CP015646
Organism Staphylococcus aureus strain 08-02300

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag A7327_RS12840 Protein ID WP_000113262.1
Coordinates 2549238..2549504 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag A7327_RS12845 Protein ID WP_000584499.1
Coordinates 2549504..2549755 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7327_RS12815 2544658..2545194 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
A7327_RS12820 2545428..2546252 - 825 WP_000594629.1 formate/nitrite transporter family protein -
A7327_RS12825 2546468..2546653 - 186 WP_000230293.1 hypothetical protein -
A7327_RS12830 2546737..2547204 - 468 WP_000153344.1 SRPBCC domain-containing protein -
A7327_RS12835 2547390..2548943 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
A7327_RS14555 2549132..2549203 - 72 Protein_2427 hypothetical protein -
A7327_RS12840 2549238..2549504 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
A7327_RS12845 2549504..2549755 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A7327_RS12850 2549920..2550021 - 102 Protein_2430 hypothetical protein -
A7327_RS12855 2550028..2550627 - 600 WP_000162810.1 DsbA family protein -
A7327_RS12860 2550646..2551008 - 363 WP_000819840.1 DUF4467 domain-containing protein -
A7327_RS12865 2551263..2552513 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
A7327_RS12870 2552610..2553341 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
A7327_RS12875 2553338..2554057 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T63313 WP_000113262.1 NZ_CP015646:c2549504-2549238 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T63313 NZ_CP015646:c2549504-2549238 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT63313 WP_000584499.1 NZ_CP015646:c2549755-2549504 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT63313 NZ_CP015646:c2549755-2549504 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References