Detailed information of TA system TA063306

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2116120..2116427
• Replicon: chromosome
• Accession: NZ_CP015646
• Organism: Staphylococcus aureus strain 08-02300

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: A7327_RS14260
• Protein ID: WP_011447039.1
• Coordinates: 2116251..2116427 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2116120..2116259 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7327_RS10475	2111686..2111865	+	180	WP_000669791.1	hypothetical protein	-
A7327_RS10485	2112176..2112436	+	261	WP_001791826.1	hypothetical protein	-
A7327_RS10490	2112489..2112839	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
A7327_RS10495	2113350..2113685	-	336	Protein_1976	SH3 domain-containing protein	-
A7327_RS10500	2114336..2114827	-	492	WP_000920038.1	staphylokinase	-
A7327_RS10505	2115018..2115773	-	756	WP_000861038.1	CHAP domain-containing protein	-
A7327_RS10510	2115785..2116039	-	255	WP_000611512.1	phage holin	-
A7327_RS10515	2116091..2116198	+	108	WP_031762631.1	hypothetical protein	-
-	2116120..2116259	+	140	NuclAT_0	-	Antitoxin
-	2116120..2116259	+	140	NuclAT_0	-	Antitoxin
-	2116120..2116259	+	140	NuclAT_0	-	Antitoxin
-	2116120..2116259	+	140	NuclAT_0	-	Antitoxin
A7327_RS14260	2116251..2116427	-	177	WP_011447039.1	putative holin-like toxin	Toxin
A7327_RS10520	2116630..2117403	-	774	WP_044033830.1	staphylococcal enterotoxin type P	-
A7327_RS10525	2117824..2118198	-	375	WP_000340977.1	hypothetical protein	-
A7327_RS10530	2118254..2118541	-	288	WP_001040255.1	hypothetical protein	-
A7327_RS10535	2118588..2118740	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see / hlb / groEL	2112489..2165426	52937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T63306 WP_011447039.1 NZ_CP015646:c2116427-2116251 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T63306 NZ_CP015646:c2116427-2116251 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT63306 NZ_CP015646:2116120-2116259 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin